癌症中 TGF-β 和细胞粘附信号通路之间的交叉对话

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-13 DOI:10.7150/ijms.96274
Jiahao Liao, Rentang Chen, Bihua Lin, Runhua Deng, Yanfang Liang, Jincheng Zeng, Sha Ma, Xianxiu Qiu
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引用次数: 0

摘要

转化生长因子-β(TGF-β)与细胞分化、迁移等过程中的细胞粘附信号通路密切相关。从机理上讲,TGF-β 以非活性形式分泌,并通过潜伏的 TGF-β 结合蛋白(LTBP)定位于细胞外基质(ECM)。然而,成熟 TGF-β 的释放对于激活 TGF-β 信号通路至关重要。这一过程需要特定的整合素(主要的细胞粘附分子(CAM)之一)来识别和激活休眠的 TGF-β。此外,TGF-β 通过调节 CAMs 的表达来调节细胞粘附能力。关键调控分子(如 Smad 蛋白、某些转录因子和非编码 RNA)的异常表达导致 TGF-β 信号通路的异常激活,从而在肿瘤发生的晚期通过上皮-间质转化(EMT)促进肿瘤的侵袭和转移能力。本文总结了肿瘤中 TGF-β 与细胞粘附信号通路之间的相互影响及其潜在的分子机制。
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Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer
Transforming growth factor-β (TGF-β) is strongly associated with the cell adhesion signaling pathway in cell differentiation, migration, etc. Mechanistically, TGF-β is secreted in an inactive form and localizes to the extracellular matrix (ECM) via the latent TGF-β binding protein (LTBP). However, it is the release of mature TGF-β that is essential for the activation of the TGF-β signaling pathway. This progress requires specific integrins (one of the main groups of cell adhesion molecules (CAMs)) to recognize and activate the dormant TGF-β. In addition, TGF-β regulates cell adhesion ability through modulating CAMs expression. The aberrant activation of the TGF-β signaling pathway, caused by abnormal expression of key regulatory molecules (such as Smad proteins, certain transcription factors, and non-coding RNAs), promotes tumor invasive and metastasis ability via epithelial-mesenchymal transition (EMT) during the late stages of tumorigenesis. In this paper, we summarize the crosstalk between TGF-β and cell adhesion signaling pathway in cancer and its underlying molecular mechanisms.
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CiteScore
7.20
自引率
4.30%
发文量
567
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