新加坡生物标志物与认知研究(BIOCIS):协议、研究设计和初步结果

Y. J. Leow, J. D. J. Wang, A. Vipin, G. K. Sandhu, S. A. Soo, D. Kumar, A. A. Mohammed, F. Z. B. Zailan, F. P. H. E. Lee, S. Ghildiyal, S. Y. Liew, C. Dang, P. Tanoto, I. Y. Z. Tan, W. F. W. Chong, Nagaendran Kandiah
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引用次数: 0

摘要

背景医学的重点正从治疗转向预防。痴呆症和阿尔茨海默病(AD)的生物标志物在可观察到的症状出现前数十年就已出现,已有证据支持药物和非药物干预治疗可改变的痴呆症风险因素。目标新加坡生物标志物与认知研究(BIOCIS)的目标是通过一项纵向研究,结合多种族东南亚人群的体液生物标志物特征、神经影像学、神经心理学和临床结果,描述认知障碍的潜在病理生物学特征。将从新加坡社区招募 2500 名年龄在 30 岁至 95 岁之间的参与者。为了调查病理表现如何与最小临床症状或无最小临床症状相反,将招募 CI 和无障碍个体。参与者将接受评估,通过神经影像学、体液生物标志物、认知评估、行为和生活方式特征、视网膜扫描和微生物组指标来确定痴呆症的生物标志物特征。结果自2022年2月开始招募以来,已有1148名参与者加入,其中包括1012名华人、62名印度人和35名马来人。平均年龄和受教育程度分别为 61.32 岁和 14.34 岁,男性占 39.8%。47.9%的人有工作,32.06%的人有痴呆症家族史。结论BIOCIS队列将有助于在东南亚人群中识别新型生物标记物、病理轨迹、痴呆症流行病学和可逆风险因素。BIOCIS 纵向数据的完成可为亚洲人群的风险分层提供见解,并有可能为公共医疗保健和精准医疗提供信息,从而在预防阿尔茨海默病和痴呆症方面为患者提供更好的治疗效果。
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Biomarkers and Cognition Study, Singapore (BIOCIS): Protocol, Study Design, and Preliminary Findings

Background

The focus of medicine is shifting from treatment to preventive care. The expression of biomarkers of dementia and Alzheimer’s disease (AD) appear decades before the onset of observable symptoms, and evidence has emerged supporting pharmacological and non-pharmacological interventions to treat modifiable risk factors of dementia. However, there is limited research on the epidemiology, clinical phenotypes, and underlying pathobiology of cognitive diseases in Asian populations.

Objectives

The objectives of the Biomarkers and Cognition Study, Singapore(BIOCIS) are to characterize the underlying pathobiology of Cognitive Impairment through a longitudinal study incorporating fluid biomarker profiles, neuroimaging, neuropsychological and clinical outcomes in a multi-ethnic Southeast Asian population.

Design, Setting, Participants

BIOCIS is a 5-year longitudinal study where participants are assessed annually. 2500 participants aged 30 to 95 will be recruited from the community in Singapore. To investigate how pathology presents with or without minimal clinical symptoms and vice versa, CI and unimpaired individuals will be recruited. Participants will undergo assessments to characterise biomarkers of dementia through neuroimaging, fluid biomarkers, cognitive assessments, behavioural and lifestyle profiles, retinal scans and microbiome indicators.

Results

Since commencement of recruitment in February 2022, 1148 participants have been enrolled, comprising 1012 Chinese, 62 Indian, and 35 Malay individuals. Mean age and education is 61.32 years and 14.34 years respectively with 39.8% males. 47.9 % of the cohort are employed and 32.06% have a family history of dementia. The prevalence of cerebral small vessel disease is 90.2% with a mean modified Fazekas white matter hyperintensity score of 4.1.

Conclusion

The BIOCIS cohort will help identify novel biomarkers, pathological trajectories, epidemiology of dementia, and reversible risk factors in a Southeast Asian population. Completion of BIOCIS longitudinal data could provide insights into risk-stratification of Asians populations, and potentially inform public healthcare and precision medicine for better patient outcomes in the prevention of Alzheimer’s disease and dementia.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
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期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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