精神分裂症神经炎症的有望标记物

IF 0.5 4区医学 Q4 NEUROSCIENCES Neurochemical Journal Pub Date : 2024-05-24 DOI:10.1134/s1819712424010185

A. V. Sakharov, S. E. Golygina

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引用次数: 0

摘要

摘要-精神分裂症的发病机制尚无单一的模式，但神经炎症被认为是该病发病的一个关键机制。我们的研究旨在分析和总结有关神经炎症标记物在精神分裂症中作用的文献数据。我们以 "神经炎症"、"细胞因子"、"趋化因子"、"微循环"、"小胶质细胞"、"神经损伤 "和 "精神分裂症 "为关键词，在 PubMed 和 e-Library.ru 数据库中搜索了 1990-2023 年间发表的文章。综述讨论了精神分裂症中神经炎症概念的综合方法，以及已知和有希望的标记物。包括本文作者在内的研究表明，微循环障碍和内皮功能障碍、细胞因子和趋化因子以及神经损伤在精神分裂症的发病机制和病程中起着重要作用。需要对上述结果进行更详细的研究，以确定神经炎症在精神分裂症中的新的神经生物学和病理功能。

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Promising Markers of Neuroinflammation in Schizophrenia

Abstract—There is no single model for the pathogenesis of schizophrenia, but neuroinflammation is considered a key mechanism in the development of this disease. The aim of our study was to analyze and summarize the literature data on the role of neuroinflammation markers in schizophrenia. We used the keywords “neuroinflammation,” “cytokines,” “chemokines,” “microcirculation,” “microglia,” “neurodestruction,” and “schizophrenia” to search for the articles published in 1990–2023 in the PubMed and e-Library.ru databases. The review discusses an integrated approach to the concept of neuroinflammation in schizophrenia with regard to known and promising markers. Studies, including those of the authors of the article, indicate a significant role of microcirculation disorders and endothelial dysfunction, cytokines and chemokines, and neurodestruction in the mechanisms of development and course of schizophrenia. The presented results require more detailed studies to establish new neurobiological and pathogenetic functions of neuroinflammation in schizophrenia.

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.