一些异噁唑衍生物的新合成及其抗氧化特性

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-05-19 DOI:10.1134/S1070428024030175

N. Uludag

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引用次数: 0

摘要

摘要利用羟胺碱和苯环上同时具有供电子和吸电子分子的2,4-二氧代-4-(4-R-苯基)丁酸乙酯，一步合成了一系列取代的5-苯基-1,2-恶唑-3-羧酸乙酯，并用DPPH法研究了产品的抗氧化性。该方法适用于大规模生产异噁唑衍生物。

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New Synthesis of Some Isoxazole Derivatives and Their Antioxidant Properties

A series of substituted ethyl 5-phenyl-1,2-oxazole-3-carboxylates were synthesized in good to excellent yields in one step using hydroxylamine base and ethyl 2,4-dioxo-4-(4-R-phenyl)butanoates bearing both electron-donating and electron-withdrawing moieties on the benzene ring, and antioxidant properties of the products were investigated by the DPPH method. The proposed method is suitable for the large-scale production of isoxazole derivatives.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.