迷迭香酸可改善单克隆抗体诱导的右心室肥大对左心室的并发症研究Wnt/β-catenin在心脏中的信号通路

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Iranian Journal of Basic Medical Sciences Pub Date : 2024-01-01 DOI:10.22038/IJBMS.2024.75201.16301
Narges Atefipour, Mahin Dianat, Mohammad Badavi, Maryam Radan, Seyyed Ali Mard
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引用次数: 0

摘要

目的:右心室肥大(RVH)通常会导致右心室甚至左心室衰竭。迷迭香酸(RA)是一种天然多酚,常见于婆婆纳科植物以及一些蕨类植物和角草中。本研究观察了RA如何影响氧化应激、左心室血流动力学功能以及单克隆腺嘌呤(MCT)诱导的RVH模型大鼠的RVH:为了诱导 RVH,大鼠腹腔注射 MCT(60 毫克/千克)。给大鼠注射生理盐水或 RA(10、15 和 30 毫克/千克,灌胃,21 天)。对麻醉大鼠记录 II 导联心电图。使用 Langendorff 仪器(恒压)测量离体心脏的血液动力学功能。对右心室肥大指数(RVHI)、超氧化物歧化酶、过氧化氢酶、谷胱甘肽的活性以及左心室中 Wnt 和 β-catenin 基因的表达进行了调查。采用 H&E 染色:结果:MCT组心电图参数和抗氧化酶活性明显下降,QTc(Q-T校正)间期、MDA(丙二醛)、RVHI和Wnt/β-catenin基因表达增加,血液动力学参数也有明显变化。RA改善了上述因素:根据研究结果,RA 可作为一种心脏保护剂,防止 RVH 引起的心血管并发症,因为它能提高心脏抗氧化酶的活性,降低血管钙化相关基因的表达。
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Rosmarinic acid ameliorates the complications of monocrotaline-induced right ventricular hypertrophy on the left ventricle: Investigating the signaling pathway of Wnt/β-catenin in the heart.

Objectives: Right ventricular hypertrophy (RVH) often results in failure of the right ventricle or even the left ventricle. Rosmarinic acid (RA), a natural polyphenol, is commonly found in Boraginaceae species and some species of ferns and hornworts. This study looked at how RA affects oxidative stress and left ventricular hemodynamic functions as well as RVH in monocrotaline (MCT) induced RVH model rats.

Materials and methods: To cause RVH, MCT (60 mg/kg) was intraperitoneally (IP) injected. Rats were given saline or RA (10, 15, and 30 mg/kg, gavage, over 21 days). In anesthetized rats, the lead II electrocardiogram was recorded. The hemodynamic functions of the isolated heart were measured using the Langendorff apparatus (at constant pressure). Investigations were made into the right ventricular hypertrophy index (RVHI), the activities of superoxide dismutase, catalase, glutathione, and Wnt and β-catenin gene expressions in the left ventricle. H&E staining was used.

Results: A significant decline in electrocardiogram parameters and anti-oxidant enzyme activities, an increase in QTc (Q-T corrected) intervals, MDA (Malondialdehyde), RVHI, and Wnt/β-catenin gene expression, and also significant changes in the hemodynamic parameters were demonstrated in the MCT group. RA improved the above-mentioned factors.

Conclusion: According to the findings, RA may act as a cardioprotective agent against cardiovascular complications brought on by RVH due to its capacity to boost the activity of cardiac anti-oxidant enzymes and decrease the expression of genes involved in vascular calcification.

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来源期刊
Iranian Journal of Basic Medical Sciences
Iranian Journal of Basic Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The Journal of "IJBMS” is a modern forum for scientific communication. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, Microbiology, Pathology, Pharmacology, Pharmaceutical Sciences, and Physiology, will be published after they have been peer reviewed. This will also include reviews and multidisciplinary research.
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