一例二肽基肽酶-4 抑制剂治疗后出现的免疫球蛋白 G4 相关肾病。

IF 1 Q4 UROLOGY & NEPHROLOGY CEN Case Reports Pub Date : 2024-05-27 DOI:10.1007/s13730-024-00889-9

Yoshifumi Ubara, Toshihiro Takeuchi, Eiko Hasegawa, Akinari Sekine, Noriko Inoue, Kiho Tanaka, Hiroki Mizuno, Yuki Oba, Masayuki Yamanouchi, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Naoki Sawa, Takehiko Wada

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引用次数: 0

摘要

一名 68 岁的 2 型糖尿病患者因肾功能减退入院。他的 IgG4 偏高（1070 mg/dL），并伴有低补体血症（CH50，25 U/mL）。肾活检显示他患有肾小管间质性肾炎，IgG4 阳性浆细胞浸润。四年后，第二次肾活检发现膜性肾病和肾小管间质性肾炎的新表现，纤维化形成加剧。六年后，患者出现了大疱性丘疹，被认为是由 DPP4 抑制剂引起的，因此停用了 DPP4 抑制剂治疗。DPP4 抑制剂的使用与肾功能的变化相关，患者被诊断为与 DPP4 抑制剂相关的 IgG4 相关性肾病。

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A case of immunoglobulin G4-related kidney disease manifesting after dipeptidyl peptidase-4 inhibitor treatment.

A 68-year-old man with type 2 diabetes mellitus was admitted with decreased renal function. He had high IgG4 (1070 mg/dL) and hypocomplementemia (CH50, 25 U/mL). Kidney biopsy showed tubulointerstitial nephritis with IgG4-positive plasma cell infiltration. Four years later, a second kidney biopsy revealed a new manifestation of membranous nephropathy and tubulointerstitial nephritis with exacerbated fibrosis formation. Six years later, the patient developed bullous pemphigoid, which was thought to be caused by DPP4 inhibitors, so DPP4 inhibitor treatment was discontinued. The use of DPP4 inhibitors correlated with changes in renal function, and the patient was diagnosed with IgG4-related kidney disease related to DPP4 inhibitors.

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来源期刊

CEN Case Reports UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.