Gustavo Zigovski, Isabela Cristina Colaço Bez, Luís Fernando Costa Garrido, Caroline Cintra Rodrigues, Angela Cristina da Fonseca de Oliveira, Paulo Evaristo Rupolo, Liliana Bury de Azevedo, Elmer Modesto Elvir Hernandez, Jansller Luiz Genova, Saulo Henrique Weber, Paulo Levi de Oliveira Carvalho, Leandro Batista Costa
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引用次数: 0
摘要
本研究旨在评估超稀释(UD)复合物作为日粮中抗菌促生长剂的替代品对保育猪生长性能、肠道健康和炎症反应的影响。实验持续了 37 天,126 头仔猪在 21 ± 1.3 d 断奶,初始体重为 5.62 ± 1.16 kg。在随机区组设计中,仔猪被分配到六个日粮处理中,七个重复,每栏三头仔猪作为实验单位。处理为:阳性对照(PC)--基础日粮+120 毫克/千克的氯羟基喹啉;阴性对照(NC)--不含添加剂的基础日粮;以及含有 4.5、6.0、7.5 或 9.0 千克 UD 添加剂/吨日粮的 NC。计算性能数据并观察每日腹泻情况。采集血液样本进行血液学分析。实验结束时,每栏宰杀一只动物,进行器官称重、pH 值测定,并采集肠道样本进行组织病理学检查。收集粪便和盲肠内容物进行微生物和抗生素分析。各处理之间的表现没有差异。在整个研究过程中,在腹泻发生率方面,UD 水平与 PC 水平相当。UD 复合物水平越高,白细胞总数越高。与 PC 相比,4.5 处理显示仔猪粪便中总肠杆菌和耐热肠杆菌数量减少,乳酸菌数量增加。与 NC 组相比,所有处理方法导致的十二指肠组织病理学改变都较少。在仔猪日粮中使用 UD 添加剂,尤其是 4.5 千克/吨的添加剂,是氯羟基喹啉的良好替代品。
Ultra-diluted complex additive in the diet reveals benefits in the intestinal tract of nursery-phase piglets.
This study aimed to assess an ultra-diluted (UD) complex, as a replacement for an antimicrobial growth promoter in diets, on growth performance, intestinal health, and inflammatory response of nursery piglets. The experiment lasted 37 days and involved 126 animals weaned at 21 ± 1.3 d, with an initial body weight of 5.62 ± 1.16 kg. Piglets were assigned to six dietary treatments in a randomized block design with seven replicates and three piglets per pen as experimental unit. The treatments were: positive control (PC)- basal diet + 120 mg/kg of chlorohydroxyquinoline; negative control (NC)- basal diet without additives; and NC containing 4.5; 6.0; 7.5 or 9.0 kg of UD additive/ton diet. Performance data were calculated, and daily diarrhea was observed. Blood samples were collected for hematological analysis. At the end of the experiment, one animal per pen was slaughtered for organ weighing, pH, and the collection of intestinal samples for histopathology. Feces and cecal contents were collected for microbiological and antibiogram analyses. There was no difference in the performance between the treatments. Throughout the study, UD levels were equal to those of PC for diarrhea occurrence. Higher levels of UD complex led to higher total leukocyte counts. The 4.5 treatment showed a reduction in total and thermotolerant Enterobacteriaceae populations in piglet feces and an increase in lactic acid bacteria compared to PC. All treatments resulted in fewer duodenal histopathological alterations than those in the NC group. The use of UD additives, especially at 4.5 kg/ton, is a good alternative to chlorohydroxyquinoline in piglet diets.
期刊介绍:
Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial.
The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.