Melissa I Ortiz-Román, Ileska M Casiano-Muñiz, Felix R Román-Velázquez
{"title":"紫外线滤光器二苯甲酮-3 对盐水虾(Artemia salina)和斑马鱼(Danio rerio)胚胎的毒性","authors":"Melissa I Ortiz-Román, Ileska M Casiano-Muñiz, Felix R Román-Velázquez","doi":"10.3390/jox14020032","DOIUrl":null,"url":null,"abstract":"<p><p>The benzophenone (BP) family, including oxybenzone (BP-3), a prevalent sunscreen ingredient and environmental contaminant, has raised concerns since the year 2005. This study investigated oxybenzone toxicity in zebrafish (<i>Danio rerio</i>) eleutheroembryos and brine shrimp (<i>Artemia salina</i>) nauplii, focusing on the LC<sub>50</sub> and developmental impacts. Zebrafish embryos (0.100-1.50 mg/L BP-3, 96 h) and <i>A. salina</i> (0.100-5.00 mg/L BP-3, 48 h) were tested with ultrasound-assisted emulsified liquid-phase microextraction (UA-ELPME) used for zebrafish tissue analysis. HPLC-DAD determined BP-3 concentrations (highest: 0.74 ± 0.13 mg/L). Although no significant zebrafish embryo mortality or hatching changes occurred, developmental effects were evident. Lethal concentrations were determined (<i>A. salina</i> LC<sub>50</sub> at 24 h = 3.19 ± 2.02 mg/L; <i>D. rerio</i> embryos LC<sub>50</sub> at 24 h = 4.19 ± 3.60 mg/L), with malformations indicating potential teratogenic effects. <i>A. salina</i> displayed intestinal tract alterations and <i>D. rerio</i> embryos exhibited pericardial edema and spinal deformities. These findings highlight oxybenzone's environmental risks, posing threats to species and ecosystem health.</p>","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"14 2","pages":"537-553"},"PeriodicalIF":6.8000,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130858/pdf/","citationCount":"0","resultStr":"{\"title\":\"Toxicity of UV Filter Benzophenone-3 in Brine Shrimp Nauplii (<i>Artemia salina</i>) and Zebrafish (<i>Danio rerio</i>) Embryos.\",\"authors\":\"Melissa I Ortiz-Román, Ileska M Casiano-Muñiz, Felix R Román-Velázquez\",\"doi\":\"10.3390/jox14020032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The benzophenone (BP) family, including oxybenzone (BP-3), a prevalent sunscreen ingredient and environmental contaminant, has raised concerns since the year 2005. This study investigated oxybenzone toxicity in zebrafish (<i>Danio rerio</i>) eleutheroembryos and brine shrimp (<i>Artemia salina</i>) nauplii, focusing on the LC<sub>50</sub> and developmental impacts. Zebrafish embryos (0.100-1.50 mg/L BP-3, 96 h) and <i>A. salina</i> (0.100-5.00 mg/L BP-3, 48 h) were tested with ultrasound-assisted emulsified liquid-phase microextraction (UA-ELPME) used for zebrafish tissue analysis. HPLC-DAD determined BP-3 concentrations (highest: 0.74 ± 0.13 mg/L). Although no significant zebrafish embryo mortality or hatching changes occurred, developmental effects were evident. Lethal concentrations were determined (<i>A. salina</i> LC<sub>50</sub> at 24 h = 3.19 ± 2.02 mg/L; <i>D. rerio</i> embryos LC<sub>50</sub> at 24 h = 4.19 ± 3.60 mg/L), with malformations indicating potential teratogenic effects. <i>A. salina</i> displayed intestinal tract alterations and <i>D. rerio</i> embryos exhibited pericardial edema and spinal deformities. These findings highlight oxybenzone's environmental risks, posing threats to species and ecosystem health.</p>\",\"PeriodicalId\":42356,\"journal\":{\"name\":\"Journal of Xenobiotics\",\"volume\":\"14 2\",\"pages\":\"537-553\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2024-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130858/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Xenobiotics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/jox14020032\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Xenobiotics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/jox14020032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Toxicity of UV Filter Benzophenone-3 in Brine Shrimp Nauplii (Artemia salina) and Zebrafish (Danio rerio) Embryos.
The benzophenone (BP) family, including oxybenzone (BP-3), a prevalent sunscreen ingredient and environmental contaminant, has raised concerns since the year 2005. This study investigated oxybenzone toxicity in zebrafish (Danio rerio) eleutheroembryos and brine shrimp (Artemia salina) nauplii, focusing on the LC50 and developmental impacts. Zebrafish embryos (0.100-1.50 mg/L BP-3, 96 h) and A. salina (0.100-5.00 mg/L BP-3, 48 h) were tested with ultrasound-assisted emulsified liquid-phase microextraction (UA-ELPME) used for zebrafish tissue analysis. HPLC-DAD determined BP-3 concentrations (highest: 0.74 ± 0.13 mg/L). Although no significant zebrafish embryo mortality or hatching changes occurred, developmental effects were evident. Lethal concentrations were determined (A. salina LC50 at 24 h = 3.19 ± 2.02 mg/L; D. rerio embryos LC50 at 24 h = 4.19 ± 3.60 mg/L), with malformations indicating potential teratogenic effects. A. salina displayed intestinal tract alterations and D. rerio embryos exhibited pericardial edema and spinal deformities. These findings highlight oxybenzone's environmental risks, posing threats to species and ecosystem health.
期刊介绍：
The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.
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