母亲年龄与后代 DNA 甲基化有关:对 PACE 联合研究结果的荟萃分析。

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology Aging Cell Pub Date : 2024-05-29 DOI:10.1111/acel.14194
Edwina Yeung, Richard J. Biedrzycki, Laura C. Gómez Herrera, Prachand Issarapu, John Dou, Irene Fontes Marques, Sohail Rafik Mansuri, Christian Magnus Page, Justin Harbs, Dennis Khodasevich, Eric Poisel, Zhongzheng Niu, Catherine Allard, Emma Casey, Fernanda Morales Berstein, Giulia Mancano, Hannah R. Elliott, Rebecca Richmond, Yiyan He, Justiina Ronkainen, Sylvain Sebert, Erin M. Bell, Gemma Sharp, Sunni L. Mumford, Enrique F. Schisterman, Giriraj R. Chandak, Caroline H. D. Fall, Sirazul A. Sahariah, Matt J. Silver, Andrew M. Prentice, Luigi Bouchard, Magnus Domellof, Christina West, Nina Holland, Andres Cardenas, Brenda Eskenazi, Lea Zillich, Stephanie H. Witt, Tabea Send, Carrie Breton, Kelly M. Bakulski, M. Daniele Fallin, Rebecca J. Schmidt, Dan J. Stein, Heather J. Zar, Vincent W. V. Jaddoe, John Wright, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Jordi Sunyer, Anke Huels, Martine Vrijheid, Sophia Harlid, Stephanie London, Marie-France Hivert, Janine Felix, Mariona Bustamante, Weihua Guan
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摘要

全球推迟生育的趋势增加了父母的生育年龄。父母的高龄可能会损害后代的健康,但其机制尚不清楚。后代 DNA 甲基化(DNAm)模式的改变可能是其中的一个原因,因为衰老与老年人配子中甲基化的变化有关。我们对妊娠和儿童表观遗传学联盟(Pregnancy and Childhood Epigenetics consortium)的 9500 多名新生儿和 2000 多名儿童(5-10 岁)的父母年龄与后代血液 DNAm 的关联进行了荟萃分析。在新生儿中,我们在 13 个基因位点中发现了 33 个 CpG 位点,这些位点的 DNAm 与新生儿的母体年龄有关(PFDR FDR = 6.92 × 10-8)。在儿童血液样本中,MTNR1B CpGs 血液 DNAm 的这些差异具有名义上的显著性(p FDR
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Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.

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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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