CFTR调节剂时代囊性纤维化治疗面临的挑战作者回复在囊性纤维化且至少有一个F508del等位基因的患者中使用eexacaftor+tezacaftor+ivacaftor的系统综述和荟萃分析在接受调节剂治疗的囊性纤维化患者中停用与继续使用高渗盐水或dornase alfa（SIMPLIFY）两项平行、多中心、开放标签、随机对照、非劣效性试验的结果评估停用高渗盐水对用力呼气容积降低者的安全性多中心、开放标签、随机对照、非劣效试验评估停用高渗盐水对 Elexacaftor/Tezacaftor/Ivacaftor 治疗后 1 秒内用力呼气容积降低者的安全性。

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