Regielly Caroline Raimundo Cognialli, Diego H Caceres, Flávio de Queiroz Telles
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引用次数: 0
摘要
背景：准确诊断副球孢子菌病对改善患者预后至关重要。通过双重免疫扩散（DID）检测副球孢子菌抗体是一种方便的诊断工具，但检测效果会因某些因素而变化：我们使用市售的副球孢子菌试剂（IMMY，美国）评估了 DID 的性能，涉及 40 份血清标本，其中 20 份来自已证实患有副球孢子菌病的患者，20 份来自未患病的患者。DID 检验的灵敏度为 90%（95% CI=68%-99%），特异性为 100%（95% CI=83%-100%）：我们的研究结果表明，使用商业试剂进行 DID 检测是一种可行的抗原球孢子虫抗体检测工具，其检测效果令人满意。
Evaluation of commercial immunodiffusion reagents for detecting serum anti-Paracoccidioides antibodies.
Background: Accurate diagnosis of paracoccidioidomycosis is crucial for improving patient outcomes. Paracoccidioides antibody detection by double immunodiffusion (DID) is a convenient diagnostic tool, but testing performance can vary based on certain factors.
Methods: We assessed DID performance using a commercially prepared Paracoccidioides reagents (IMMY, USA), involving 40 serum specimens, including 20 from patients with proven paracoccidioidomycosis and 20 from patients without the disease. The DID test demonstrated a sensitivity of 90% (95% CI=68%-99%) and a specificity of 100% (95% CI=83%-100%).
Conclusions: Our findings suggest that DID using commercial reagents may provide a feasible tool with satisfactory testing performance for anti-Paracoccidioides antibody detection.
期刊介绍：
The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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