{"title":"抗惊厥药物毒性","authors":"Laurence A. Gray","doi":"10.1016/j.mpmed.2024.03.009","DOIUrl":null,"url":null,"abstract":"<div><p>Anticonvulsant medications are used in the treatment of epilepsy as neuropathic pain, migraine and psychiatric illness. Anticonvulsants suppress neuronal excitation to reduce the likelihood of seizure activity. Generally, management is supportive, with correction of physiological and metabolic parameters. Drug concentrations can help guide specific treatments such as <span>l</span>-carnitine (for valproate) and multiple-dose activated charcoal (for carbamazepine, phenytoin and phenobarbital). Extracorporeal treatments can be used to enhance elimination.</p></div>","PeriodicalId":74157,"journal":{"name":"Medicine (Abingdon, England : UK ed.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anticonvulsant toxicity\",\"authors\":\"Laurence A. Gray\",\"doi\":\"10.1016/j.mpmed.2024.03.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Anticonvulsant medications are used in the treatment of epilepsy as neuropathic pain, migraine and psychiatric illness. Anticonvulsants suppress neuronal excitation to reduce the likelihood of seizure activity. Generally, management is supportive, with correction of physiological and metabolic parameters. Drug concentrations can help guide specific treatments such as <span>l</span>-carnitine (for valproate) and multiple-dose activated charcoal (for carbamazepine, phenytoin and phenobarbital). Extracorporeal treatments can be used to enhance elimination.</p></div>\",\"PeriodicalId\":74157,\"journal\":{\"name\":\"Medicine (Abingdon, England : UK ed.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine (Abingdon, England : UK ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1357303924000690\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine (Abingdon, England : UK ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357303924000690","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anticonvulsant medications are used in the treatment of epilepsy as neuropathic pain, migraine and psychiatric illness. Anticonvulsants suppress neuronal excitation to reduce the likelihood of seizure activity. Generally, management is supportive, with correction of physiological and metabolic parameters. Drug concentrations can help guide specific treatments such as l-carnitine (for valproate) and multiple-dose activated charcoal (for carbamazepine, phenytoin and phenobarbital). Extracorporeal treatments can be used to enhance elimination.
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