敲除 PRR11 可通过抑制 Akt/mTOR 信号通路诱导胶质瘤细胞自噬

IF 0.5 4区医学 Q4 NEUROSCIENCES Neurochemical Journal Pub Date : 2024-05-27 DOI:10.1134/s1819712424020077

Zongxi Li, Lingxuan Ren, Lie Zhang

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引用次数: 0

摘要

摘要神经胶质瘤是最常见的原发性颅脑肿瘤。了解胶质瘤发生和发展的分子机制将为有效治疗胶质瘤提供策略。富脯氨酸蛋白11（PRR11）是一种在不同肿瘤中广泛过表达的蛋白。TCGA数据分析显示，PRR11在胶质瘤组织中表达上调，但其作用仍有待进一步研究。本文研究了 PRR11 在胶质瘤进展中的作用及其机制。我们发现PRR11在胶质瘤细胞中过度表达。抑制PRR11可抑制胶质瘤细胞的生长，并诱导细胞周期停滞。我们进一步发现，PRR11的消减可诱导胶质瘤细胞的自噬。此外，PRR11的敲除抑制了Akt/mTOR通路的激活，从而抑制了胶质瘤细胞的增殖。我们认为PRR11可以作为胶质瘤治疗的靶点。

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Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway

Abstract

Glioma is the most common type of primary craniocerebral tumor. Understanding the molecular mechanisms of glioma occurrence and development will provide strategies for effectively treating glioma. Proline-rich protein 11 (PRR11) is a protein which is widely overexpressed in different tumors. TCGA data analysis showed that PRR11 expression was up-regulated in glioma tissues, but its role still needs to be further studied. Here, the role of PRR11 in glioma progression and the mechanism were investigated. We found PRR11 was overexpressed in glioma cells. Depletion of PRR11 suppressed the growth of glioma cells as well as induced cell cycle arrest. We further found PRR11 ablation induced the autophagy of glioma cells. Furthermore, knockdown of PRR11 restrained the activation of Akt/mTOR pathway, thereby suppressing the proliferation of glioma cells. We thought PRR11 could serve as a target for glioma therapy.

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来源期刊

Neurochemical Journal 医学-神经科学

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components. The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.