Gaoqing Luo, Ming Gao, Qinghua Lin, Xiaoyue Xu, Yanfei Cai
{"title":"慢性扁桃体炎患者接受球形切除术与传统扁桃体切除术的比较：对血清应激指标、炎症介质水平、术后疼痛和并发症的影响","authors":"Gaoqing Luo, Ming Gao, Qinghua Lin, Xiaoyue Xu, Yanfei Cai","doi":"10.1134/s1819712424020089","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for the treatment of chronic tonsillitis (CT). The clinical data of 87 patients with CT treated in our hospital from November 2020 to October 2022 were retrospectively analyzed, and patients were divided into two groups based on the surgical protocol. Among them, 43 patients treated with traditional tonsillectomy were set as control group, and 44 patients treated with coblation tonsillectomy were set as study group. We compared perioperative indexes, serum stress indicators (PCT, Cor, PGE2, PGF2α), inflammatory mediator levels (CRP, TNF-α, WBC, NLR), pain level (VAS score), immune function (T lymphocyte subpopulation) at different time points, and complications between the two groups. The study group had significantly lower intraoperative bleeding, shorter operation time, feeding and hospitalization time, and longer time for complete regression of yellow-white scabs than the control group (<i>P</i> < 0.05). At 1 day postoperatively, the study group had significantly lower levels of serum PCT, Cor, CRP, TNF-α, WBC, and NLR than the control group, while PGE2 and PGF2α levels decreased in both groups (<i>P</i> < 0.05). At 1, 3, 5, and 7 day after surgery, the VAS scores were significantly lower in the study group than in the control group (<i>P</i> < 0.05). At 1 week after surgery, the study group had significantly higher levels of CD3+, CD4+, and CD4+/CD8+ and significantly lower levels of CD8+ than the control group (<i>P</i> < 0.05). The complication rate in the study group (4.55%) was significantly lower than that in the control group (20.93%) (<i>P</i> < 0.05). Coblation tonsillectomy is less traumatic for CT patients, effectively reduces the degree of postoperative pain, decreases stress response, suppresses inflammatory response, improves immune function, reduces complications, and promotes postoperative recovery compared with traditional tonsillectomy.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications\",\"authors\":\"Gaoqing Luo, Ming Gao, Qinghua Lin, Xiaoyue Xu, Yanfei Cai\",\"doi\":\"10.1134/s1819712424020089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for the treatment of chronic tonsillitis (CT). The clinical data of 87 patients with CT treated in our hospital from November 2020 to October 2022 were retrospectively analyzed, and patients were divided into two groups based on the surgical protocol. Among them, 43 patients treated with traditional tonsillectomy were set as control group, and 44 patients treated with coblation tonsillectomy were set as study group. We compared perioperative indexes, serum stress indicators (PCT, Cor, PGE2, PGF2α), inflammatory mediator levels (CRP, TNF-α, WBC, NLR), pain level (VAS score), immune function (T lymphocyte subpopulation) at different time points, and complications between the two groups. The study group had significantly lower intraoperative bleeding, shorter operation time, feeding and hospitalization time, and longer time for complete regression of yellow-white scabs than the control group (<i>P</i> < 0.05). At 1 day postoperatively, the study group had significantly lower levels of serum PCT, Cor, CRP, TNF-α, WBC, and NLR than the control group, while PGE2 and PGF2α levels decreased in both groups (<i>P</i> < 0.05). At 1, 3, 5, and 7 day after surgery, the VAS scores were significantly lower in the study group than in the control group (<i>P</i> < 0.05). At 1 week after surgery, the study group had significantly higher levels of CD3+, CD4+, and CD4+/CD8+ and significantly lower levels of CD8+ than the control group (<i>P</i> < 0.05). The complication rate in the study group (4.55%) was significantly lower than that in the control group (20.93%) (<i>P</i> < 0.05). Coblation tonsillectomy is less traumatic for CT patients, effectively reduces the degree of postoperative pain, decreases stress response, suppresses inflammatory response, improves immune function, reduces complications, and promotes postoperative recovery compared with traditional tonsillectomy.</p>\",\"PeriodicalId\":19119,\"journal\":{\"name\":\"Neurochemical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurochemical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1134/s1819712424020089\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s1819712424020089","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
Abstract
This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for the treatment of chronic tonsillitis (CT). The clinical data of 87 patients with CT treated in our hospital from November 2020 to October 2022 were retrospectively analyzed, and patients were divided into two groups based on the surgical protocol. Among them, 43 patients treated with traditional tonsillectomy were set as control group, and 44 patients treated with coblation tonsillectomy were set as study group. We compared perioperative indexes, serum stress indicators (PCT, Cor, PGE2, PGF2α), inflammatory mediator levels (CRP, TNF-α, WBC, NLR), pain level (VAS score), immune function (T lymphocyte subpopulation) at different time points, and complications between the two groups. The study group had significantly lower intraoperative bleeding, shorter operation time, feeding and hospitalization time, and longer time for complete regression of yellow-white scabs than the control group (P < 0.05). At 1 day postoperatively, the study group had significantly lower levels of serum PCT, Cor, CRP, TNF-α, WBC, and NLR than the control group, while PGE2 and PGF2α levels decreased in both groups (P < 0.05). At 1, 3, 5, and 7 day after surgery, the VAS scores were significantly lower in the study group than in the control group (P < 0.05). At 1 week after surgery, the study group had significantly higher levels of CD3+, CD4+, and CD4+/CD8+ and significantly lower levels of CD8+ than the control group (P < 0.05). The complication rate in the study group (4.55%) was significantly lower than that in the control group (20.93%) (P < 0.05). Coblation tonsillectomy is less traumatic for CT patients, effectively reduces the degree of postoperative pain, decreases stress response, suppresses inflammatory response, improves immune function, reduces complications, and promotes postoperative recovery compared with traditional tonsillectomy.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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