获得性穿孔性皮肤病:来自一个中心的 95 名患者的临床和组织病理学分析。

IF 2.5 4区 医学 Q2 DERMATOLOGY Dermatology practical & conceptual Pub Date : 2024-04-01 DOI:10.5826/dpc.1402a100
Yusuf Can Edek, Yağmur Aypek, Betül Öğüt, Özlem Erdem, Esra Adışen
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引用次数: 0

摘要

简介获得性穿孔性皮肤病(APD)是一种以胶原蛋白、弹力纤维和角蛋白等真皮结缔组织物质经表皮排出为特征的疾病,可观察到瘙痒性皮损:本研究旨在阐明 APD 的临床、组织病理学和皮肤镜特征,确定相关的系统性疾病,并找出治疗方案:本研究是一项单中心回顾性、观察性、横断面研究。我们对一家三甲医院 2004 年 1 月至 2022 年 6 月间所有可获得的 APD 病例进行了评估:共有 95 名确诊 APD 患者被纳入研究。60%的患者为女性,40%为男性。确诊时的中位年龄为 63.1 岁(35-85 岁)。最常见的病变部位是下肢,86.31%的患者发现了下肢病变。84.21%的患者伴有全身性疾病。最常见的全身性疾病是 2 型糖尿病(65.26%)。抗组胺药和局部皮质类固醇激素是最常用的治疗药物:结论:真皮结缔组织成分经表皮脱落是 APD 的一个特征,该病通常表现为瘙痒性丘疹和结节,伴有中央角化结痂或栓塞。APD 的诊断需要临床检查和组织学检查。APD 通常伴有全身并发症。有几种局部和全身用药可用于治疗 APD,但有时治疗可能具有挑战性。
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Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center.

Introduction: Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions.

Objectives: In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options.

Methods: This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital.

Results: A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents.

Conclusions: Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.

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