Ming Ren, Lu-Lu Sun, Yu-Chi Tu, Li Feng, Li-Jun Yao
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引用次数: 0
摘要
缺血再灌注损伤（IRI）是一种复杂的现象。尽管研究人员早已意识到 IRI 的存在，但其复杂的信号传递事件和潜在的治疗靶点仍是一个活跃的研究领域。活性氧在 IRI 中的作用引起了科学家们的极大兴趣。最新研究发现，IRI 产生的活性氧可激活氧化还原敏感性瞬时受体电位通道（氧化还原 TRPs）。氧化还原 TRPs 的发现为了解 IRI 的机理提供了一个新的视角。
Redox TRPs in Ischemia-Reperfusion Injury and Their Pharmacological Value.
Ischemia-reperfusion injury (IRI) is a complex phenomenon. Although researchers have long been aware of IRI, its complex signaling events and potential therapeutic targets are still an active research area. The role of reactive oxygen species in IRI has garnered great interest among scientists. Recent studies have found that reactive oxygen species produced by IRI can activate redox-sensitive transient receptor potential channels (redox TRPs). The discovery of redox TRPs provides a new perspective for understanding the mechanism of IRI.
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