[对急性 ST 段抬高型心肌梗死患者使用机械溶栓疗法与仅使用 IIB/IIIA 糖蛋白抑制剂相比,院内重大心脏事件的发生率]。

Arcenio A Lendo-López, José E Galván-García, Anival Trujillo-García, Luis F Aguilar-Aguilar, Jorge A Garay-Hansen, Omar Ramírez-Lastra, Óscar Zapana-Céspedes, Bernardo Meléndez-Mendoza, Ramiro J Fajardo-Losada, Salvador I Sandoval-Hernández, Alan A León-Bojorquez, Luis A González-Serrato, Kevin A Zurroza-Luna, Juan M Palacios-Rodríguez
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引用次数: 0

摘要

目的确定急性ST段抬高型心肌梗死患者使用机械溶栓加IIb/IIIa糖蛋白抑制剂与仅使用IIb/IIIa糖蛋白抑制剂的院内主要心脏不良事件(MACE)发生率:回顾性、观察性、队列分析研究,对象为2021年10月至2022年12月期间接受治疗的急性ST段抬高型心肌梗死患者,血管造影血栓TIMI 5级:共纳入 237 名患者。113例患者使用了血栓吸入术,124例患者未使用。81.6%的患者为男性。31.9%的患者使用了血栓吸入术,30.6%的患者没有使用(RR:1.05;IC95%:0.61-1.93;P = 0.840)。使用血栓抽吸术的患者恶性心律失常发生率为 8%,而未使用血栓抽吸术的患者为 1.6%(RR:5.27;IC95%:1.11-24.97;P = 0.020):在减少ST段抬高急性心肌梗死和高血栓负荷患者的院内MACE发生率方面,同时使用IIb/IIIa糖蛋白抑制剂与仅使用IIb/IIIa糖蛋白抑制剂的效果相似。该研究存在一些局限性,因此应谨慎对待研究结果。
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[Incidence of intrahospitalary major cardiac events with the use of mechanic thromboaspiration versus only use of IIB/IIIA glucoprotein inhibitors on patients with acute ST elevation myocardial infarction].

Objective: To identify the incidence of in-hospital major adverse cardiac events (MACE) with the use of mechanic thromboaspiration plus IIb/IIIa glycoprotein inhibitors versus only use of IIb/IIIa glycoprotein inhibitors on patients with acute ST elevation myocardial infarction.

Method: Retrospective, observational, cohort analytic study, on patients with acute ST elevation myocardial infarction that had angiography thrombus TIMI 5 grade, treated between October 2021 and December 2022.

Results: A total of 237 patients were included. In 113 patients thromboaspiration were used, 124 patients didn't used. 81.6% were men. In-hospital MACE occurred on 31.9% of patients with thromboaspiration use vs. 30.6% on patients with no use (RR: 1.05; IC95%: 0.61-1.93; p = 0.840). Incidence of malignant arrhythmias were of 8% with thromboaspiration use vs. 1.6% on patients with no use (RR: 5.27; IC95%: 1.11-24.97; p = 0.020).

Conclusions: The use of thromboaspiration on concomitant treatment with IIb/IIIa glycoprotein inhibitors was similar with only IIb/IIIa glycoprotein inhibitors in reducing incidence of in-hospital MACE on patients with ST elevation acute myocardial infarction and high thrombus burden. The study has several limitations, so results should be taken with caution.

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