Shasha Zhang*, Simon Shun Wang Leung and Dale Vanyo,
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Despite the widespread application of diboron reagents in Suzuki–Miyaura borylation reactions, the thermal stability of diboron compounds is poorly understood. Seven commonly used diboron reagents were selected to investigate their thermal stability using Differential Scanning Calorimetry (DSC). Tetrahydroxydiboron (BBA) was specifically chosen for comprehensive safety characterization, considering the high thermal risk identified during the DSC screening. The decomposition of BBA was further explored using DSC in conjunction with Advanced Thermokinetics Software (AKTS), as well as Accelerating Rate Calorimetry (ARC) and Differential Accelerating Rate Calorimetry (DARC). Key safety parameters, such as the temperature at which the time to the maximum rate is 24 h (TMR24 and TD24), were estimated. Consistent results for TMR24 were obtained across various methods, affirming the reliability of these techniques in the kinetic analysis. DARC and ARC testing reveal an exceptionally rapid thermal runaway for BBA to the extent that the self-heating rate cannot be tracked within the instrument’s limits. Furthermore, BBA was found to be insensitive to impact or friction. This study presents the general methodology and specific findings for BBA, with the aim of providing industry guidance for conducting process safety assessment and ensuring the safe utilization of diboron reagents during process development and scale-up.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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