基于大麻籽或亚麻籽油的冻干液晶的临床应用:评估其对皮肤屏障功能的影响。

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY Acta Pharmaceutica Pub Date : 2024-05-30 Print Date: 2024-06-01 DOI:10.2478/acph-2024-0014
Mercedes Vitek, Mirjam Gosenca Matjaž
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引用次数: 0

摘要

皮肤的主要功能是在人体与环境之间形成有效的屏障。屏障功能受损是特应性皮炎等皮肤病发病的先决条件,特应性皮炎是最常见的炎症性皮肤病,其特点是皮肤屏障功能障碍。特应性皮炎严重影响患者的生活质量,因此,人们对开发新型给药系统以改善治疗效果的兴趣与日俱增。在此,研究人员首次以健康的成年受试者为对象,采用双盲、干预、前后对比、单组试验的方法,对八种新型溶胀性液晶(LCC)进行了研究,并采用了每天两次的应用方案。LCCs 由具有皮肤再生特性的成分组成,呈片状微结构,特别适合用于真皮层。研究确定了 LCC 对 TEWL、SC 水合作用、红斑指数、黑色素指数和耐受性的短期和长期影响,并与基线进行了比较。含油量和卵磷脂/吐温 80 混合物最高的 LCC 脱颖而出,其 TEWL 值显著降低了 2 倍,皮肤红斑水平在短期和长期暴露中的下降最为明显。因此,它们在临床上很有可能被用作治疗 AD 的新型给药系统,能够修复皮肤屏障功能。
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Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function.

The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients' quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.

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来源期刊
Acta Pharmaceutica
Acta Pharmaceutica PHARMACOLOGY & PHARMACY-
CiteScore
5.20
自引率
3.60%
发文量
20
审稿时长
>12 weeks
期刊介绍: AP is an international, multidisciplinary journal devoted to pharmaceutical and allied sciences and contains articles predominantly on core biomedical and health subjects. The aim of AP is to increase the impact of pharmaceutical research in academia, industry and laboratories. With strong emphasis on quality and originality, AP publishes reports from the discovery of a drug up to clinical practice. Topics covered are: analytics, biochemistry, biopharmaceutics, biotechnology, cell biology, cell cultures, clinical pharmacy, drug design, drug delivery, drug disposition, drug stability, gene technology, medicine (including diagnostics and therapy), medicinal chemistry, metabolism, molecular modeling, pharmacology (clinical and animal), peptide and protein chemistry, pharmacognosy, pharmacoepidemiology, pharmacoeconomics, pharmacodynamics and pharmacokinetics, protein design, radiopharmaceuticals, and toxicology.
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