用于透皮给药 Prinsepia Utilis Rogle Seed Oil 的 Ethosomes 的制备和特性分析,可改善紫外线引起的皮肤损伤。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-30 DOI:10.1208/s12249-024-02822-w
Qianqian Fang, You Li, Fei Xiong, Xiaolong Hu, Ying Song, Wenbing Shen, Haijuan Dong, Xinhong Shi, Hao Wang
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摘要

Prinsepia utilis seed oil(PUSO)是从 Prinsepia utilis Rogle seed 中提取的一种天然药物,一直用于治疗皮肤病。本研究旨在制备高载药量的乙素体作为水溶性透皮载体,以提高 PUSO 的透皮给药效果。研究采用冷冻法制备了载药乙硫体(PEs),并以夹持效率(EE)为因变量,通过正交实验设计对其进行了优化。采用优化配方制备的聚乙二醇具有良好的稳定性,在透射电子显微镜(TEM)下呈球形,平均粒径为 39.12 ± 0.85 nm,PDI 为 0.270 ± 0.01,zeta 电位为 -11.3 ± 0.24 mV,EE 为 95.93 ± 0.43%。与 PUSO 悬浮液相比,PE 明显增加了 PUSO 的表皮沉积(P < 0.001)。此外,最佳配方对紫外线 B(UVB)照射引起的小鼠皮肤宏观和组织病理学变化有明显的改善作用。因此,聚乙烯是治疗紫外线 B 诱导的皮肤炎症的一种很有前景的治疗方法,具有产业化的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Formulation and Characterization of Ethosomes for Transdermal Delivery of Prinsepia Utilis Rogle Seed Oil with Ameliorative Effects against UVB-Induced Skin Damage

Prinsepia utilis seed oil (PUSO) is a natural medication obtained from Prinsepia utilis Rogle seed, which has been used for the treatment of skin diseases. The study aims to prepare ethosomes with high drug loading as a water-soluble transdermal vehicle to enhance the transdermal delivery of PUSO. PUSO-loaded ethosomes (PEs) were prepared using a cold method, and optimized by an orthogonal experimental design with entrapment efficiency (EE) as the dependent variable. The PEs prepared with the optimized formulation showed good stability, with a spherical shape under transmission electron microscopy (TEM), average particle size of 39.12 ± 0.85 nm, PDI of 0.270 ± 0.01, zeta potential of -11.3 ± 0.24 mV, and EE of 95.93 ± 0.43%. PEs significantly increased the skin deposition of PUSO compared to the PUSO suspension (P < 0.001). Moreover, the optimum formula showed significant ameliorative effects on ultraviolet B (UVB) irradiation-associated macroscopic and histopathological changes in mice skin. Therefore, PEs represent a promising therapeutic approach for the treatment of UVB-induced skin inflammation, with the potential for industrialization.

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4.30%
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