{"title":"益生菌、益生元和合成益生菌对伤口感染的影响:系统综述。","authors":"Marzie Mahdizade Ari, Soheila Shahroodian, Roghayeh Afifirad, Parisa Asadollahi, Arezoo Asadi, Talihe Darbandi, Roya Ghanavati, Atieh Darbandi","doi":"10.2174/0113892010279946240507115337","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review aimed to summarize the currently available evidence on the effect of oral probiotic therapy on infected wound healing among patients who underwent surgery.</p><p><strong>Materials and methods: </strong>An electronic search was conducted for articles published during 2010- 2022 in Embase, PubMed/Medline, Scopus, Web of Science, and Google Scholar using the keywords \"probiotics,\" \"prebiotics,\" \"synbiotics,\" and \"wound infection.\" The titles and abstracts of 2625 articles were screened, and 22 publications that fulfilled the inclusion criteria were included.</p><p><strong>Results: </strong>The current review provides evidence of the beneficial effects of probiotics on wound infection, significantly reducing the duration of antibiotic usage and the length of hospital stay for patients, with no serious side effects reported. 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引用次数: 0
摘要
简介:本系统综述旨在总结目前关于口服益生菌疗法对手术患者感染伤口愈合的影响的现有证据:本系统性综述旨在总结口服益生菌疗法对手术患者感染性伤口愈合效果的现有证据:使用关键词 "益生菌"、"益生元"、"合成益生菌 "和 "伤口感染",对 Embase、PubMed/Medline、Scopus、Web of Science 和 Google Scholar 中 2010-2022 年间发表的文章进行了电子检索。对 2625 篇文章的标题和摘要进行了筛选,符合纳入标准的 22 篇出版物被纳入其中:本综述提供了益生菌对伤口感染有益的证据,可显著缩短抗生素的使用时间和患者的住院时间,且无严重副作用的报道。各种手术(如腹部伤口手术、结肠直肠癌切除术、胰腺周围肿瘤治疗、肝脏和胆管切除术、胰十二指肠切除术、食管造口术、牙科伤口手术、整形手术和烧伤)后的伤口感染都会受到益生菌使用的积极影响。虽然在某些情况下,改善效果在统计学上并不显著,但总体而言,服用益生菌在这方面似乎令人满意:益生菌通过招募 M2 巨噬细胞来防止病原体的生长并保持伤口无菌,M2 巨噬细胞能产生抗炎标志物并增强吞噬细胞的活性。此外,益生菌还能减少细菌从其生态位转移到其他区域,并抑制导致细菌入侵的细菌介质的产生。
The Effects of Probiotics, Prebiotics, and Synbiotics on Wound Infection: A Systematic Review.
Introduction: This systematic review aimed to summarize the currently available evidence on the effect of oral probiotic therapy on infected wound healing among patients who underwent surgery.
Materials and methods: An electronic search was conducted for articles published during 2010- 2022 in Embase, PubMed/Medline, Scopus, Web of Science, and Google Scholar using the keywords "probiotics," "prebiotics," "synbiotics," and "wound infection." The titles and abstracts of 2625 articles were screened, and 22 publications that fulfilled the inclusion criteria were included.
Results: The current review provides evidence of the beneficial effects of probiotics on wound infection, significantly reducing the duration of antibiotic usage and the length of hospital stay for patients, with no serious side effects reported. Wound infections following various surgeries, such as abdominal wound surgery, colorectal cancer resection, periampullary neoplasms treatment, liver and bile duct resection, pancreaticoduodenectomy, esophagostomy, dental wound surgery, plastic surgery, and burns, are shown to be positively affected by probiotic usage. Although, in some cases, the improvements were not statistically significant, overall, the administration of probiotics appears to be satisfactory in this regard.
Conclusion: Probiotics demonstrate the ability to prevent the growth of pathogens and maintain wound space sterility by recruiting M2 macrophages, which produce anti-inflammatory markers and enhance the activity of phagocytic cells. Additionally, probiotics can reduce bacterial translocation from their niche to other areas and inhibit the production of bacterial mediators that lead to bacterial invasion.
期刊介绍:
Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:
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Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.