{"title":"从油辣木根中提取的葡萄糖络氨酸对类似阿尔茨海默氏症的病理学进行硅学和药代动力学研究。","authors":"Chintalapati Manogna, Thirumal Margesan","doi":"10.2144/fsoa-2023-0255","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> The aim of this research is to investigate the potential of glucomoringin, derived from <i>Moringa oleifera</i>, as a therapeutic agent for Alzheimer's disease through <i>in silico</i> analysis. <b>Materials & methods:</b> This study employs <i>in silico</i> or computational methodologies, including pkCSM, Swiss ADME, OSIRIS<sup>®</sup> property explorer, PASS online web resource and MOLINSPIRATION<sup>®</sup> software, to predict the pharmacokinetic characteristics and biological activity of glucomoringin. <b>Results & conclusion:</b> Molecular docking indicates strong binding to <i>I-1β</i> and the pharmacokinetic profile shows cytochrome P450 enzyme inhibition, prompting further research for dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility in modulating essential pathways. glucomoringin's potential for Alzheimer's treatment, emphasizing the need for additional empirical research.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137837/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>In silico</i> and pharmacokinetic studies of glucomoringin from <i>Moringa oleifera</i> root for Alzheimer's disease like pathology.\",\"authors\":\"Chintalapati Manogna, Thirumal Margesan\",\"doi\":\"10.2144/fsoa-2023-0255\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> The aim of this research is to investigate the potential of glucomoringin, derived from <i>Moringa oleifera</i>, as a therapeutic agent for Alzheimer's disease through <i>in silico</i> analysis. <b>Materials & methods:</b> This study employs <i>in silico</i> or computational methodologies, including pkCSM, Swiss ADME, OSIRIS<sup>®</sup> property explorer, PASS online web resource and MOLINSPIRATION<sup>®</sup> software, to predict the pharmacokinetic characteristics and biological activity of glucomoringin. <b>Results & conclusion:</b> Molecular docking indicates strong binding to <i>I-1β</i> and the pharmacokinetic profile shows cytochrome P450 enzyme inhibition, prompting further research for dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility in modulating essential pathways. glucomoringin's potential for Alzheimer's treatment, emphasizing the need for additional empirical research.</p>\",\"PeriodicalId\":12568,\"journal\":{\"name\":\"Future Science OA\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137837/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Science OA\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2144/fsoa-2023-0255\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Science OA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2144/fsoa-2023-0255","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
In silico and pharmacokinetic studies of glucomoringin from Moringa oleifera root for Alzheimer's disease like pathology.
Aim: The aim of this research is to investigate the potential of glucomoringin, derived from Moringa oleifera, as a therapeutic agent for Alzheimer's disease through in silico analysis. Materials & methods: This study employs in silico or computational methodologies, including pkCSM, Swiss ADME, OSIRIS® property explorer, PASS online web resource and MOLINSPIRATION® software, to predict the pharmacokinetic characteristics and biological activity of glucomoringin. Results & conclusion: Molecular docking indicates strong binding to I-1β and the pharmacokinetic profile shows cytochrome P450 enzyme inhibition, prompting further research for dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility in modulating essential pathways. glucomoringin's potential for Alzheimer's treatment, emphasizing the need for additional empirical research.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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