糖皮质激素增加导致肝脏 AdipoR2 减少,从而介导了社会心理压力对血清胆固醇升高的影响。

IF 3.8 3区 医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-05-28 DOI:10.1016/j.mce.2024.112282
Qi Wei Guo , Jia Lin , Yi Lin Shen , Yan Jiang Zheng , Xu Chen , Mi Su , Ji Cheng Zhang , Jin Hua Wang , Hui Tang , Guo Ming Su , Zheng Ke Li , Ding Zhi Fang
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引用次数: 0

摘要

了解社会心理压力对血清胆固醇的影响可能会对心理障碍与内分泌疾病之间的关系提供有价值的见解。然而,这些影响及其内在机制尚未得到阐明。在这里,我们发现,在社会心理应激小鼠模型中,血清皮质酮、总胆固醇和低密度脂蛋白胆固醇(LDL-C)会升高。此外,肝脏中由 AdipoR2 介导的 AMPK 和 PPARα 信号通路也发生了改变,同时低密度脂蛋白胆固醇清除率降低,胆固醇合成增加。这些变化在用皮质醇和 AdipoR 激动剂培养的野生型和 AdipoR2 过表达 HepG2 细胞中得到了进一步验证,并最终通过用皮质酮处理野生型和肝特异性 AdipoR2 过表达小鼠得到了证实。我们的结论是,糖皮质激素的增加通过抑制 AdipoR2 介导的 AMPK 和 PPARα 信号传导来降低 LDL-C 的清除率并增加肝脏中胆固醇的合成,从而介导社会心理压力对血清胆固醇升高的影响。
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Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol

Understanding the effects of psychosocial stress on serum cholesterol may offer valuable insights into the relationship between psychological disorders and endocrine diseases. However, these effects and their underlying mechanisms have not been elucidated yet. Here we show that serum corticosterone, total cholesterol and low-density lipoprotein cholesterol (LDL-C) are elevated in a mouse model of psychosocial stress. Furthermore, alterations occur in AdipoR2-mediated AMPK and PPARα signaling pathways in liver, accompanied by a decrease in LDL-C clearance and an increase in cholesterol synthesis. These changes are further verified in wild-type and AdipoR2 overexpression HepG2 cells incubated with cortisol and AdipoR agonist, and are finally confirmed by treating wild-type and hepatic-specific AdipoR2 overexpression mice with corticosterone. We conclude that increased glucocorticoid mediates the effects of psychosocial stress to elevate serum cholesterol by inhibiting AdipoR2-mediated AMPK and PPARα signaling to decrease LDL-C clearance and increase cholesterol synthesis in liver.

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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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