植物酚作为原药设计的促进剂。

Bharat V Dhokchawle, Punit Mishra, Renny J Daniel
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引用次数: 0

摘要

原药设计是克服药物发现过程中的挑战或增强已批准药物的不良特性的一种有利可图的方法。本综述旨在向研究人员介绍可用于原药合成的天然植物酚类载体及其优势。当用作原药时,植物酚具有多种优势,因为它们还具有抗氧化和镇痛特性,可以天然获取,其安全性也已得到证实。薄荷醇、百里酚、丁香酚、愈创木酚、芝麻酚、香兰素和伞形酮等几种植物酚具有多种有益特性,被广泛用于食品加工和医药领域。在本综述中,我们列出了用于原药合成的所有原药类型,并对植物酚进行了详细综述,这可能有助于研究人员根据自己的需要和候选药物的适用性来选择植物酚。
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Phytophenols as Promoieties for Prodrug Design.

One lucrative method for overcoming challenges in drug discovery or for enhancing undesirable properties of already-approved medications is prodrug design. The goal of this review is to present researchers with a profile of naturally occurring Phytophenols as carriers that would be used for prodrug synthesis as well as their advantages. Phytophenols offer several advantages when used as promoieties as they also possess antioxidant and analgesic properties, they are obtained naturally and their safety profile is well established. Several phytophenols like menthol, thymol, eugenol, guaiacol, sesamol, vanillin, and umbelliferone are some of the phytophenols that have several beneficial properties and are extensively employed in the field of food processing and medicine. In the current review, we have listed all types of promoieties that are used for prodrug synthesis and phytophenols are reviewed in detail, which may help researchers to select phytophenols based on their need and suitability for drug candidates.

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