Xue-yan Huang , Lu-lu Xue , Rui-fang Ma , Jing-shan Shi , Ting-hua Wang , Liu-lin Xiong , Chang-yin Yu
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引用次数: 0
摘要
阿尔茨海默病(AD)是最常见的痴呆症类型,其病因多种多样,目前尚未完全明了。在之前的一项研究中,我们发现奇迹果种子(MFS)的短期治疗对阿兹海默病模型小鼠有治疗作用,但这种作用背后的确切机制仍不清楚。在这项研究中,我们旨在确定长期服用神奇果实籽对 AD 模型小鼠的疗效和安全性。多种细胞因子和趋化因子与 AD 的发病有关。先前的研究已经验证了C-X-C趋化因子受体4型(CXCR4)的表达水平与AD疾病严重程度之间的相关性。在这项研究中,我们观察到AD模型组海马组织中1n的CXCR4表达上调,并在MFS治疗后逆转。此外,CXCR4基因敲除可改善AD模型小鼠的认知功能,而MFS显示出调节CXCR4表达的能力。最后,我们的研究结果表明,CXCR4基因敲除和长期MFS治疗在治疗AD模型小鼠方面效果相当。总之,这项研究证明了长期使用 MFS 对 AD 模型小鼠的治疗效果和安全性。MFS治疗和随后的CXCR4表达减少在大脑中显示出神经保护作用,突出了它们作为AD治疗靶点的潜力。
Inhibition of CXCR4: A perspective on miracle fruit seed for Alzheimer's disease treatment
Alzheimer's disease (AD) is the most prevalent type of dementia, and its causes are currently diverse and not fully understood. In a previous study, we discovered that short-term treatment with miracle fruit seed (MFS) had a therapeutic effect on AD model mice, however, the precise mechanism behind the effect remains unclear. In this research, we aimed to establish the efficacy and safety of long-term use of MFS in AD model mice. A variety of cytokines and chemokines have been implicated in the development of AD. Previous studies have validated a correlation between the expression levels of C-X-C chemokine receptor type 4 (CXCR4) and disease severity in AD. In this research, we observed an upregulation of CXCR4 expression in hippocampal tissues in the AD model group, which was then reversed after MFS treatment. Moreover, CXCR4 knockout led to improving cognitive function in AD model mice, and MFS showed the ability to regulate CXCR4 expression. Finally, our findings indicate that CXCR4 knockout and long-term MFS treatment produce comparable effects in treating AD model mice. In conclusion, this research demonstrates that therapeutic efficacy and safety of long-term use of MFS in AD model mice. MFS treatment and the subsequent reduction of CXCR4 expression exhibit a neuroprotective role in the brain, highlighting their potential as therapeutic targets for AD.
期刊介绍:
Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.