眼部 RNA 纳米医学:治疗眼部疾病的工程输送纳米平台。

IF 14.3 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Trends in biotechnology Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI:10.1016/j.tibtech.2024.05.002
Yiming Zhang, Yesi Shi, Muhammad M Khan, Fan Xiao, Wei Chen, Wei Tao, Ke Yao, Na Kong
{"title":"眼部 RNA 纳米医学:治疗眼部疾病的工程输送纳米平台。","authors":"Yiming Zhang, Yesi Shi, Muhammad M Khan, Fan Xiao, Wei Chen, Wei Tao, Ke Yao, Na Kong","doi":"10.1016/j.tibtech.2024.05.002","DOIUrl":null,"url":null,"abstract":"<p><p>Ocular disorders remain a major global health challenge with unmet medical needs. RNA nanomedicine has shown significant therapeutic benefits and safety profiles in patients with complex eye disorders, already benefiting numerous patients with gene-related eye disorders. The effective delivery of RNA to the unique structure of the eye is challenging owing to RNA instability, off-target effects, and ocular physiological barriers. Specifically tailored RNA medication, coupled with sophisticated engineered delivery platforms, is crucial to guide and advance developments in treatments for oculopathy. Herein we review recent advances in RNA-based nanomedicine, innovative delivery strategies, and current clinical progress and present challenges in ocular disease therapy.</p>","PeriodicalId":23324,"journal":{"name":"Trends in biotechnology","volume":" ","pages":"1439-1452"},"PeriodicalIF":14.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ocular RNA nanomedicine: engineered delivery nanoplatforms in treating eye diseases.\",\"authors\":\"Yiming Zhang, Yesi Shi, Muhammad M Khan, Fan Xiao, Wei Chen, Wei Tao, Ke Yao, Na Kong\",\"doi\":\"10.1016/j.tibtech.2024.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ocular disorders remain a major global health challenge with unmet medical needs. RNA nanomedicine has shown significant therapeutic benefits and safety profiles in patients with complex eye disorders, already benefiting numerous patients with gene-related eye disorders. The effective delivery of RNA to the unique structure of the eye is challenging owing to RNA instability, off-target effects, and ocular physiological barriers. Specifically tailored RNA medication, coupled with sophisticated engineered delivery platforms, is crucial to guide and advance developments in treatments for oculopathy. Herein we review recent advances in RNA-based nanomedicine, innovative delivery strategies, and current clinical progress and present challenges in ocular disease therapy.</p>\",\"PeriodicalId\":23324,\"journal\":{\"name\":\"Trends in biotechnology\",\"volume\":\" \",\"pages\":\"1439-1452\"},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tibtech.2024.05.002\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.tibtech.2024.05.002","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

眼部疾病仍然是一项重大的全球健康挑战,其医疗需求尚未得到满足。RNA 纳米药物已在复杂眼疾患者中显示出显著的治疗效果和安全性,并已使众多基因相关眼疾患者受益。由于 RNA 的不稳定性、脱靶效应和眼部生理障碍,要将 RNA 有效地输送到结构独特的眼部具有挑战性。专门定制的 RNA 药物以及复杂的工程化递送平台对于指导和推动眼病治疗的发展至关重要。在此,我们回顾了基于 RNA 的纳米药物的最新进展、创新给药策略、当前的临床进展以及眼病治疗面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Ocular RNA nanomedicine: engineered delivery nanoplatforms in treating eye diseases.

Ocular disorders remain a major global health challenge with unmet medical needs. RNA nanomedicine has shown significant therapeutic benefits and safety profiles in patients with complex eye disorders, already benefiting numerous patients with gene-related eye disorders. The effective delivery of RNA to the unique structure of the eye is challenging owing to RNA instability, off-target effects, and ocular physiological barriers. Specifically tailored RNA medication, coupled with sophisticated engineered delivery platforms, is crucial to guide and advance developments in treatments for oculopathy. Herein we review recent advances in RNA-based nanomedicine, innovative delivery strategies, and current clinical progress and present challenges in ocular disease therapy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Trends in biotechnology
Trends in biotechnology 工程技术-生物工程与应用微生物
CiteScore
28.60
自引率
1.20%
发文量
198
审稿时长
1 months
期刊介绍: Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
期刊最新文献
Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care. Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures. Distillation for in situ recovery of volatile fermentation products. Understanding bacterial ecology to combat antibiotic resistance dissemination. High-throughput screening strategies for plastic-depolymerizing enzymes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1