SEOM 癌症厌食-腹痛综合征临床指南(2023 年)。

IF 2.8 3区 医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2024-11-01 Epub Date: 2024-06-01 DOI:10.1007/s12094-024-03502-8
Ainara Soria Rivas, Yolanda Escobar Álvarez, Ana Blasco Cordellat, Margarita Majem Tarruella, Kevin Molina Mata, Marta Motilla de la Cámara, Mª Del Mar Muñoz Sánchez, Marta Zafra Poves, Carmen Beato Zambrano, Luis Cabezón Gutierrez
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引用次数: 0

摘要

癌症相关厌食-痛风综合征(CACS)是一种使人衰弱的病症,多达 80% 的晚期癌症患者都会受到这种病症的困扰。CACS 的特点是进行性体重减轻、肌肉萎缩和代谢异常,严重影响患者的生活质量和治疗效果。这篇全面的综述介绍了其复杂的生理病理,阐明了其分期和诊断方法。CACS 表现为三个不同的阶段:恶病质前期、恶病质确立期和恶病质难治期。早期发现是有效干预的关键,筛查工具、营养评估和专业评价对早期发现有很大帮助。诊断过程揭示了导致 CACS 的代谢失调和肿瘤诱发因素之间复杂的相互作用。根据患者个体情况制定的管理策略包括一系列营养干预措施。其中包括饮食咨询、口服营养补充剂,必要时还包括肠内营养和慎重使用肠外营养。针对热量摄入、蛋白质需求和必需营养素的具体建议可应对 CACS 带来的独特挑战。虽然可以考虑使用醋酸甲孕酮等药物,但需要对其潜在风险进行仔细评估。本综述的核心内容是强调必须采用全面和个性化的方法来管理 CACS,在对患者病情有细致入微的了解的基础上整合营养干预和药物治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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SEOM clinical guidelines for cancer anorexia-cachexia syndrome (2023).

Cancer-related anorexia-cachexia syndrome (CACS) is a debilitating condition afflicting up to 80% of advanced-stage cancer patients. Characterized by progressive weight loss, muscle wasting, and metabolic abnormalities, CACS significantly compromises patients' quality of life and treatment outcomes. This comprehensive review navigates through its intricate physiopathology, elucidating its stages and diagnostic methodologies. CACS manifests in three distinct stages: pre-cachexia, established cachexia, and refractory cachexia. Early detection is pivotal for effective intervention and is facilitated by screening tools, complemented by nutritional assessments and professional evaluations. The diagnostic process unravels the complex interplay of metabolic dysregulation and tumor-induced factors contributing to CACS. Management strategies, tailored to individual patient profiles, encompass a spectrum of nutritional interventions. These include dietary counseling, oral nutritional supplements, and, when necessary, enteral nutrition and a judicious use of parenteral nutrition. Specific recommendations for caloric intake, protein requirements, and essential nutrients address the unique challenges posed by CACS. While pharmacological agents like megestrol acetate may be considered, their use requires careful evaluation of potential risks. At its core, this review underscores the imperative for a holistic and personalized approach to managing CACS, integrating nutritional interventions and pharmacological strategies based on a nuanced understanding of patient's condition.

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来源期刊
CiteScore
6.20
自引率
2.90%
发文量
240
审稿时长
1 months
期刊介绍: Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
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