Tung-Lung Chen, Salal Hasan Khudaida and Chie-Shaan Su*,
{"title":"抗癌药物对甲苯磺酰胺与苯甲酰胺、异烟酰胺或水杨酰胺的二元固液平衡测定","authors":"Tung-Lung Chen, Salal Hasan Khudaida and Chie-Shaan Su*, ","doi":"10.1021/acs.jced.4c00036","DOIUrl":null,"url":null,"abstract":"<p >Understanding the solid–liquid equilibrium (SLE) of active pharmaceutical ingredients (APIs) with excipients or other synergistic APIs is crucial for drug design and development. In this study, a poorly water-soluble anticancer API, <i>p</i>-toluenesulfonamide, was chosen as the model compound. SLE data and the eutectic conditions for three binary mixtures, <i>p</i>-toluenesulfonamide (1) + benzamide (2) (<i>T</i><sub>E</sub> = 354.2 K, <i>x</i><sub>1E</sub> = 0.453); <i>p</i>-toluenesulfonamide (1) + isonicotinamide (2) (<i>T</i><sub>E</sub> = 368.4 K, <i>x</i><sub>1E</sub> = 0.510); <i>p</i>-toluenesulfonamide (1) + salicylamide (2) (<i>T</i><sub>E</sub> = 371.7 K, <i>x</i><sub>1E</sub> = 0.538), were measured and reported using the differential scanning calorimetry (DSC) method. Simple eutectic behaviors were observed in these systems, with the eutectic and liquidus temperatures presented for each binary mixture at various compositions. The experimental eutectic composition was identified based on Tammann plots using the enthalpy values obtained from DSC measurements. Subsequently, the experimental liquidus temperatures were correlated using the Wilson and nonrandom two-liquid (NRTL) activity coefficient models, yielding the average absolute deviation in temperature (AADT) of less than 0.6%. These new SLE data provide valuable information for designing and developing drug formulations of <i>p</i>-toluenesulfonamide, thereby exploring potential applications.</p>","PeriodicalId":42,"journal":{"name":"Journal of Chemical & Engineering Data","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.jced.4c00036","citationCount":"0","resultStr":"{\"title\":\"Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide\",\"authors\":\"Tung-Lung Chen, Salal Hasan Khudaida and Chie-Shaan Su*, \",\"doi\":\"10.1021/acs.jced.4c00036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Understanding the solid–liquid equilibrium (SLE) of active pharmaceutical ingredients (APIs) with excipients or other synergistic APIs is crucial for drug design and development. In this study, a poorly water-soluble anticancer API, <i>p</i>-toluenesulfonamide, was chosen as the model compound. SLE data and the eutectic conditions for three binary mixtures, <i>p</i>-toluenesulfonamide (1) + benzamide (2) (<i>T</i><sub>E</sub> = 354.2 K, <i>x</i><sub>1E</sub> = 0.453); <i>p</i>-toluenesulfonamide (1) + isonicotinamide (2) (<i>T</i><sub>E</sub> = 368.4 K, <i>x</i><sub>1E</sub> = 0.510); <i>p</i>-toluenesulfonamide (1) + salicylamide (2) (<i>T</i><sub>E</sub> = 371.7 K, <i>x</i><sub>1E</sub> = 0.538), were measured and reported using the differential scanning calorimetry (DSC) method. Simple eutectic behaviors were observed in these systems, with the eutectic and liquidus temperatures presented for each binary mixture at various compositions. The experimental eutectic composition was identified based on Tammann plots using the enthalpy values obtained from DSC measurements. Subsequently, the experimental liquidus temperatures were correlated using the Wilson and nonrandom two-liquid (NRTL) activity coefficient models, yielding the average absolute deviation in temperature (AADT) of less than 0.6%. These new SLE data provide valuable information for designing and developing drug formulations of <i>p</i>-toluenesulfonamide, thereby exploring potential applications.</p>\",\"PeriodicalId\":42,\"journal\":{\"name\":\"Journal of Chemical & Engineering Data\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.acs.org/doi/epdf/10.1021/acs.jced.4c00036\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical & Engineering Data\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jced.4c00036\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical & Engineering Data","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jced.4c00036","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide
Understanding the solid–liquid equilibrium (SLE) of active pharmaceutical ingredients (APIs) with excipients or other synergistic APIs is crucial for drug design and development. In this study, a poorly water-soluble anticancer API, p-toluenesulfonamide, was chosen as the model compound. SLE data and the eutectic conditions for three binary mixtures, p-toluenesulfonamide (1) + benzamide (2) (TE = 354.2 K, x1E = 0.453); p-toluenesulfonamide (1) + isonicotinamide (2) (TE = 368.4 K, x1E = 0.510); p-toluenesulfonamide (1) + salicylamide (2) (TE = 371.7 K, x1E = 0.538), were measured and reported using the differential scanning calorimetry (DSC) method. Simple eutectic behaviors were observed in these systems, with the eutectic and liquidus temperatures presented for each binary mixture at various compositions. The experimental eutectic composition was identified based on Tammann plots using the enthalpy values obtained from DSC measurements. Subsequently, the experimental liquidus temperatures were correlated using the Wilson and nonrandom two-liquid (NRTL) activity coefficient models, yielding the average absolute deviation in temperature (AADT) of less than 0.6%. These new SLE data provide valuable information for designing and developing drug formulations of p-toluenesulfonamide, thereby exploring potential applications.
期刊介绍:
The Journal of Chemical & Engineering Data is a monthly journal devoted to the publication of data obtained from both experiment and computation, which are viewed as complementary. It is the only American Chemical Society journal primarily concerned with articles containing data on the phase behavior and the physical, thermodynamic, and transport properties of well-defined materials, including complex mixtures of known compositions. While environmental and biological samples are of interest, their compositions must be known and reproducible. As a result, adsorption on natural product materials does not generally fit within the scope of Journal of Chemical & Engineering Data.