Hafiz Muhammad Zohaib, Madiha Saqlain, Maroof Ahmad Khan, Samina Qamar, Sara Masood, Mubashar Ilyas, Yu-Meng Xu and Hui Li*,
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引用次数: 0
摘要
螺旋结构是 DNA 和其他生物材料非常重要的基本结构特征,也是手性的起源之一。为了了解螺旋的形成机理,人们设计并构建了多样化的螺旋结构。这一领域的挑战之一是合理解释单链 DNA 和水螺旋。在 DNA 碱基配对之前形成水螺旋的可能性是一个引人入胜的前景。在这项工作中,我们设计并研究了三种基于核苷酸 dTMP 的配位聚合物。它们的单晶结构显示,复合物 1 和 3 是一维配位聚合物,而复合物 2 则是二维配位聚合物。复合物 1 和 2 是配位螺旋。重要的是,水螺旋被包裹在其中。络合物 1 中既有 P 水螺旋,也有 M 水螺旋;而络合物 2 中只有 M 水螺旋。值得注意的是,复合物 3 表现出配位螺旋和水螺旋的缠结,然后呈现出假水螺旋。根据晶体学分析,我们研究了配位螺旋和水螺旋在晶格中的团结关系。构建合子限制了核碱基的取向,并且缺乏足够的立体空间来限制客体水分子。首次观察到了一种新型核碱基配对,即胸腺嘧啶-胸腺嘧啶配对(T-motif)。根据溶液和结晶固体状态下的 CD 光谱,对这些复合物的固有和超分子手性进行了讨论。复合物 2 中的水螺旋在 CD 光谱中呈现出特征性结果。这些研究成果有助于探索和理解 DNA 的结构和特性以及螺旋的形成机理。
Solidarity of the Coordination Helix and Water Helix in the Nucleotide Coordination Polymer
Helix structure is a very important and fundamental structural feature of DNA and other biomaterials and is also one of the origins of chirality. Diversiform helix structures have been designed and constructed to understand the mechanism of helix formation. One of the challenges in this field is rationalizing single-stranded DNA and water helix. The possibility of water helix formation preceding the base pairing in DNA is an intriguing prospect. In this work, three coordination polymers based on the nucleotide dTMP have been designed and studied. Their single-crystal structures revealed that complexes 1 and 3 are 1D coordination polymers while complex 2 is a 2D coordination polymer. Complexes 1 and 2 are the coordination helixes. Importantly, the water helixes are enclosed in them. Both P and M water helixes exist in complex 1; only the M-water helix is in complex 2. It is worth noting that complex 3 exhibits the entanglement of coordination helixes and water helixes and then presents a pseudowater helix. The solidarity of the coordination helix and water helix in the crystal lattice has been investigated based on crystallography analysis. The building synthons limit the orientation of the nucleobase and lack adequate stereospace to confine the guest water molecules. A new type of nucleobase pairing, thymine–thymine, named T-motif, has been observed for the first time. The inherent and supramolecular chirality of these complexes have been discussed according to CD spectra in both solution and crystallized solid states. The water helix in complex 2 exhibits characteristic outcomes in the CD spectrum. The research results contribute to exploring and understanding the DNA structure and properties and the mechanism of helix formation.
期刊介绍:
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.