Development and Validation of an Individual Socioeconomic Deprivation Index (ISDI) in the NIH's All of Us Data Network.

Many of the existing composite social determinant of health indices, such as Area Deprivation Index, are constrained by their reliance on geographic approximations and American Community Survey data. This study builds on the body of literature around deprivation indices to construct an individual socioeconomic deprivation index (ISDI) within the NIH's All of Us Data Network by using weighted multiple correspondence analysis on SDOH data elements collected at the participant level. In this study, the correlation between ISDI and another area-approximated index is assessed to the extent possible, along with the changes in an AI models performance due to stratified sampling based on ISDI quintiles. Individual level deprivation indices may have a wide range of utility particularly in the context of precision medicine in both centralized and distributed data networks.