多巴胺、乙酰胆碱和GABA在迟发性运动障碍发展中的作用的新进展。

J Scheel-Krüger, J Arnt
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引用次数: 53

摘要

本文将介绍迟发性运动障碍可能的解剖学基础的各种新发现。结果表明,纹状体具有异质性,大鼠模型的咬、咬、舔活动综合征涉及纹状体内各种多巴胺(DA)、胆碱能和gaba能系统与中脑边缘和中脑皮层系统之间的复杂平衡。
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New aspects on the role of dopamine, acetylcholine, and GABA in the development of tardive dyskinesia.

In this paper various new findings on the possible anatomical substrates of tardive dyskinesia will be presented. The results show that the striatum is heterogeneously organized, and the syndromes of biting, gnawing, and licking activities in the rat model involve a complex balance between various dopamine (DA), cholinergic, and GABAergic systems within the striatum and the mesolimbic and mesocortical systems.

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Tardive dyskinesia: reversible and irreversible. Receptor-binding profiles of neuroleptics. Pathophysiological mechanisms underlying tardive dyskinesia. Chemical and structural changes in the brain in patients with movement disorder. Medical treatment of dystonia.
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