Blanca Rodríguez-Fernández , Gonzalo Sánchez-Benavides , Patricia Genius , Carolina Minguillon , Karine Fauria , Immaculata De Vivo , Arcadi Navarro , Jose Luis Molinuevo , Juan Domingo Gispert , Aleix Sala-Vila , Natalia Vilor-Tejedor , Marta Crous-Bou , for the ALFA study
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Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
Introduction
Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.
Methods
A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.
Results
Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.
Discussion
Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.
期刊介绍：
Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.
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