内镜鼻胆管引流术(ENBD)和内镜逆行胆道引流术(ERBD)在治疗急性胆管炎中的回顾性比较

IF 0.7 4区 材料科学 Q3 Materials Science Materials Express Pub Date : 2024-06-01 DOI:10.1166/mex.2024.2667
Rui Li, Chengchen Xu, Menglu Zhao, Jian Zhang, Shiyi Sun, Bing Li, Yinghai Xie
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引用次数: 0

摘要

内镜下鼻胆管引流术(ENBD)和内镜下逆行胆道引流术(ERBD)可迅速缓解梗阻,促进胆汁引流,降低胆管内压力。在本研究中,为了评估塑料胆道支架对内镜逆行胆道造影术(ERCP)后实性胆管炎患者胆总管结石复发率的影响,我们对比分析了ENBD和ERBD在炎症缓解率、并发症发生率、二次或多次内镜碎石成功率等方面的有效性和安全性。这项回顾性研究共纳入了 347 名接受 ENBD 和 ERBD 的患者。所有参与者都接受了术前评估,包括血液检查、心电图、腹部超声波检查、CT 扫描、核磁共振成像或 MRCP。此外,还使用基于纳米磁珠的免疫测定法测定了血清 CRP 和淀粉酶水平。我们发现,ENBD 组的结石清除成功率(90.8% 对 72.7%)高于 ERBD 组(P 0.05)。ERBD组和ENBD组在术前和术后炎症指标(总胆红素、直接胆红素、白细胞、中性粒细胞、CRP和血清淀粉酶)方面无明显差异。此外,ERCP术后胰腺炎在ERBD组和ENBD组之间存在显著差异。这些结果表明,ENBD 和 ERBD 都能有效提高临床疗效。此外,纳米磁珠在血清指标检测中也有很好的应用前景,可提高检测效率。
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A retrospective comparison of endoscopic nasobiliary drainage (ENBD) and endoscopic retrograde biliary drainage (ERBD) in the treatment of acute cholangitis
Endoscopic nasobiliary drainage (ENBD) and endoscopic retrograde biliary drainage (ERBD) can rapidly alleviate obstruction, facilitate bile drainage, and reduce pressure in the bile duct. In this study, to evaluate the effect of plastic biliary stent on the recurrence rate of choledocholithiasis in patients with actual cholangitis after endoscopic retrograde cholangioangiography (ERCP), we a comparative analysis of the efficacy and safety between ENBD and ERBD in inflammatory remission rate, complication rate, and success rate of secondary or multiple endoscopic lithotomy. A total of 347 patients undergoing ENBD and ERBD were enrolled in this retrospective study. Preoperative assessments including blood tests, electrocardiography, abdominal ultrasonography, CT scans, MRI, or MRCP were conducted on all participants. Additionally, serum CRP and amylase levels were measured using a magnetic nanobead-based immunoassay. We found that The success rate of stone removal in the ENBD group was higher than that in the ERBD group (90.8% vs. 72.7%) (P <0.0001). The remission rate of inflammation in the ERBD group (100.0%) was higher than that in the ENBD group (98.7%) (P >0.05). No significant difference was observed between the ERBD group and the ENBD group in preoperative and postoperative inflammatory indexes (total bilirubin, direct bilirubin, white blood cells, neutrophils, CRP, and serum amylase). Moreover, there were significant differences in post-ERCP pancreatitis between the ERBD group and ENBD group. These results suggest that both ENBD and ERBD can effectively improve clinical efficacy. Moreover, magnetic nanobeads have good application in serum index detection to increase detection efficiency.
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Materials Express
Materials Express NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
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