探讨滥用 wegovy 和 ozempic 进行体重管理的意外后果:综述

Sarthak A. Kute, Madhura S. Chothave, Prajakta B. Rote, Anupama A. Kapadnis, Vaishnavi V. Kale
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引用次数: 0

摘要

近年来,胰高血糖素样肽-1(GLP-1)受体激动剂已成为体重管理的理想选择,不仅能控制血糖,还能显著减轻体重。在这些药物中,Wegovy(semaglutide)和Ozempic(semaglutide)因其促进体重减轻的疗效而备受关注,即使是没有糖尿病的患者也不例外。然而,在标签外使用这些药物进行体重管理引发了一些有关其安全性、疗效和长期影响的问题和担忧。本综述旨在探讨 GLP-1 激动剂在体重管理方面的复杂性,重点关注其作用机制、临床证据、安全性、用药注意事项、潜在的相互作用以及未来发展方向。
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EXPLORING THE UNINTENDED CONSEQUENCES OF MISUSE OF WEGOVY AND OZEMPIC IN WEIGHT MANAGEMENT: A COMPREHENSIVE REVIEW
In recent years, Glucagon-Like Peptide-1 (GLP-1) receptor agonists have emerged as promising options for weight management, offering not only glycemic control benefits but also significant reductions in body weight. Among these agents, Wegovy (semaglutide) and Ozempic (semaglutide) have gained attention for their efficacy in promoting weight loss, even in individuals without diabetes. However, the off-label use of these medications for weight management raises several questions and concerns regarding their safety, efficacy, and long-term effects. This comprehensive review aims to explore the complexities of GLP-1 agonists in weight management, focusing on their mechanism of action, clinical evidence, safety profile, dosing considerations, potential interactions, and future directions.
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