18F-FDG PET/CT 在为 PUO 病因学提供针对性方法方面的作用。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-08-01 Epub Date: 2024-05-17 DOI:10.1097/MNM.0000000000001855
Dikhra Khan, Ankita Phulia, Suraj Kumar, Sulochana Sarswat, Sivasankar Kv, Sambit Sagar
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引用次数: 0

摘要

目的:本研究旨在评估 18F- 氟脱氧葡萄糖 PET/ 计算机断层扫描(18F-FDG PET/CT)在有针对性地诊断不明原因热病(PUO)病因方面的潜在作用:这项前瞻性研究共纳入了 573 名 PUO 患者,平均年龄(39.40±4.6)岁。患者使用专用混合扫描仪接受了 FDG PET/CT 扫描。PET/CT 数据由经验丰富的核医学医生解读。研究分析了FDG PET/CT对适当活检部位的指导作用,并评估了PET/CT结果与组织病理学检查的一致性:结果:在 573 名患者中,有 219 名患者得到了最终诊断,包括恶性肿瘤、感染性病因、非感染性炎症病因 (NIID) 和癌前病变。FDG PET/CT 在指导临床医生确定适当的活检部位方面发挥了重要作用,有助于提高诊断率。PET/CT 发现与组织病理学检查结果的一致性强调了 PET/CT 在确定 PUO 潜在病因方面的无创诊断潜力。总体而言,50.05%的病例中,FDG PET/CT 有助于指导适当的活检部位或使第一鉴别诊断与最终诊断一致:本研究强调了 FDG PET/CT 在提供有针对性的 PUO 诊断方法方面的重要作用,展示了其在指导临床医生选择合适的活检部位和提高诊断率方面的潜力。研究结果强调了将 FDG PET/CT 纳入 PUO 诊断路径的重要性,最终将改善患者管理和预后。有必要开展进一步的前瞻性研究来验证这些结果,并完善 FDG PET/CT 在 PUO 诊断中的应用。
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Role of 18 F-FDG PET/CT for providing a targeted approach for etiology of PUO.

Aim: This study aimed to evaluate the potential role of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in providing a targeted approach for diagnosing the etiology of Pyrexia of Unknown Origin (PUO).

Methods: A total of 573 PUO patients were included in this ambispective study, with a mean age of 39.40 ± 4.6 years. Patients underwent FDG PET/CT scans using dedicated hybrid scanners. PET/CT data were interpreted by experienced nuclear medicine physicians. The study analyzed the guidance provided by FDG PET/CT for appropriate biopsy sites and assessed concordance between PET/CT findings and histopathological examination.

Results: Out of the 573 patients, a final diagnosis was reached for 219 patients, including malignancy, infectious causes, noninfectious inflammatory causes (NIID), and precancerous conditions. FDG PET/CT played a crucial role in guiding clinicians to appropriate biopsy sites, contributing to a higher diagnostic yield. Concordance between PET/CT findings and histopathological examination emphasized the noninvasive diagnostic potential of PET/CT in identifying underlying causes of PUO. Overall, FDG PET/CT contributed to guiding the appropriate site of biopsy or concordance of the first differential diagnosis with the final diagnosis in 50.05% of cases.

Conclusion: This study highlights the valuable role of FDG PET/CT in providing a targeted approach for diagnosing PUO, showcasing its potential in guiding clinicians towards appropriate biopsy sites and improving the diagnostic yield. The findings underscore the importance of integrating FDG PET/CT into the diagnostic pathway for PUO, ultimately enhancing patient management and outcomes. Further prospective studies are necessary to validate these results and refine the integration of FDG PET/CT in the diagnosis of PUO.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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