[狼疮性肾炎中的NETosis]。

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Terapevticheskii Arkhiv Pub Date : 2024-06-03 DOI:10.26442/00403660.2024.05.202699

T M Reshetnyak, K S Nurbaeva, I V Ptashnik, A A Kudrieva, A A Belogurov, A M Lila, E L Nasonov

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引用次数: 0

摘要

目的：评估系统性红斑狼疮（SLE）患者体内 MPO-DNA 复合物的水平及其与狼疮性肾炎（LN）的相关性：研究对象包括77名系统性红斑狼疮患者，其中30名系统性红斑狼疮患者不伴有抗磷脂综合征（APS），47名系统性红斑狼疮患者伴有APS，20名健康人作为对照组。采用酶联免疫吸附法检测血清中的 MPO-DNA 复合物：结果：与健康对照组相比，系统性红斑狼疮患者血清中 MPO-DNA 复合物的水平明显更高（P=0.001）。在系统性红斑狼疮患者中，有 30 人（39%）的 MPO-DNA 复合物水平升高。MPO-DNA 复合物的升高与 LN 病史明显相关（p=0.009）。此外，在纳入研究的患者中，有 20 人患有活动性 LN，而 MPO-DNA 复合物水平升高的患者比 MPO-DNA 复合物浓度未升高的患者更有可能患有活动性 LN [30 人中有 12 人（40%），47 人中有 8 人（17%），χ2=5.029；P=0.034]。MPO-DNA 复合物水平升高与蛋白尿、血尿、细胞性血细胞/粒细胞铸型和无菌性白细胞尿之间存在关联。在活动性 LN 患者中发现 MPO-DNA 复合物与 SLEDAI-R 直接相关（rs=0.497；p=0.026）：结论：39%的系统性红斑狼疮患者体内MPO-DNA复合物水平升高。结论：39%的系统性红斑狼疮患者体内检测到 MPO-DNA 复合物水平升高，这些患者在病史中和被纳入研究时有较高的 LN 患病率。根据SLEDAI-R，MPO-DNA复合物水平与LN活性之间存在相关性，这表明MPO-DNA复合物可作为评估系统性红斑狼疮肾损伤活性的生物标志物。

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[NETosis in lupus nephritis].

Aim: To evaluate the levels of MPO-DNA complex in patients with systemic lupus erythematosus (SLE) and its association with the presence of lupus nephritis (LN).

Materials and methods: The study included 77 patients with SLE, of whom 30 had SLE without anti phospholipid syndrome (APS), 47 had SLE with APS, and 20 were healthy individuals serving as the control group. The MPO-DNA complex in the serum was investigated using ELISA.

Results: The levels of MPO-DNA complex in serum were significantly higher in patients with SLE compared to healthy controls (p=0.001). Among the patients with SLE, 30 (39%) had elevated levels of MPO-DNA complex. The presence of elevated MPO-DNA complex was significantly associated with the presence of a history of LN (p=0.009). Moreover, among the patients included in the study, 20 had active LN, and patients with elevated MPO-DNA complex levels were more likely to have active LN than patients without elevated MPO-DNA complex concentrations [12 (40%) of 30 vs 8 (17%) of 47, χ²=5.029; p=0.034]. An association was found between elevated levels of MPO-DNA complex and the presence of proteinuria, hematuria, cellular hematic/granular casts and aseptic leukocyturia. A direct correlation of MPO-DNA complex with SLEDAI-R was found in patients with active LN (r_s=0.497; p=0.026).

Conclusion: Elevated levels of MPO-DNA complex were detected in 39% of patients with SLE. These patients had a higher prevalence of LN in their medical history and at the time of inclusion in the study. The correlation between MPO-DNA complex levels and the activity of LN according to SLEDAI-R indicates the potential role of MPO-DNA complex as a biomarker for assessing the activity of renal damage in SLE.

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.