沙特阿拉伯利雅得首次报告的食源性肉毒杆菌疫情:汲取的经验教训。

IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Epidemiology and Global Health Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI:10.1007/s44197-024-00255-z
Nadeem Gul Dar, Sarah H Alfaraj, Khulood Naser Alboqmy, Nazia Khanum, Faleh Alshakrah, Hassan Abdallah, Mohammad Hosni Badawi, Ohoud Mohammed Alharbi, Khadijh Ahmed Alshiekh, Abdullah M Alsallum, Ahmed Hassan Shrahili, Zeidan A Zeidan, Zaki Abdallah, Ahmed Ali Majrashi, Ziad A Memish
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引用次数: 0

摘要

背景:沙特阿拉伯王国以前从未报道过肉毒杆菌中毒。这种罕见的食源性疾病有时是致命的,由神经毒素引起,主要是食用自家罐装的水果、蔬菜、乳制品和海鲜产品所致,可导致瘫痪:本研究旨在评估 2024 年在利雅得因食用沙特阿拉伯利雅得当地一家知名连锁餐厅的蛋黄酱而患肉毒中毒的患者的临床特征:我们对利雅得第一卫生组所有食源性肉毒中毒住院病例的病历进行了回顾性分析,并对患者或其护理人员进行了访谈。每位患者都填写了一份标准病例报告表,其中包含人口统计学、临床方面、肉毒杆菌检测结果和接触类型等信息。数据评估采用了描述性统计方法。疫情爆发期间,利雅得第一卫生组群医院共收治了19名食源性疾病患者。经过全面体检,每个病例都被怀疑是肉毒中毒:结果:19 名疑似食源性疾病患者中有 8 人完全符合沙特阿拉伯公共卫生局(Weqaya)规定的肉毒中毒病例定义要求。在这 8 名患者中,男性 2 人(占 25%),女性 6 人(占 75%),平均年龄为 23.25±9.29 岁(范围:12-38 岁)。八名患者均出现吞咽困难(100%),七名患者出现构音障碍、全身乏力、恶心和呕吐(88%),四名患者出现复视(50%),三名患者出现胃部不适(38%)。在这 8 例病例中,6 例需要插管,1 例模拟脑死亡,2 例病情稳定。通过在受污染的食物中检测肉毒杆菌孢子,证实了肉毒杆菌孢子是导致疫情爆发的原因:结论:复视和构音障碍是肉毒中毒最常见的早期症状。结论:复视和构音障碍是肉毒中毒最常见的早期症状,早期表现可能包括没有任何肌肉骨骼症状的呼吸道症状,或恶心、呕吐和定向障碍。
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The First Reported Foodborne Botulism Outbreak in Riyadh, Saudi Arabia: Lessons Learned.

Background: Botulism has not been previously reported in the Kingdom of Saudi Arabia. This rare and sometimes fatal foodborne illness is caused by neurotoxins and primarily results from consuming home-canned fruits, vegetables, dairy, and seafood products & it can lead to paralysis.

Objective: The purpose of this study was to evaluate the clinical features of patients who developed botulism in Riyadh in 2024 after consuming mayonnaise from a well-known local chain of restaurants in Riyadh, Saudi Arabia.

Methods: We conducted a retrospective analysis of medical records and interviewed patients or their attendants for all hospitalized cases of foodborne botulism at Riyadh First Health Cluster. For each patient, a standard case report form was completed, containing information on demographics, clinical aspects, botulinum test results, and type of exposure. Descriptive statistics were applied to assess the data. During the outbreak, nineteen patients with foodborne diseases were admitted to Riyadh First Health Cluster Hospitals. Following thorough physical examinations, botulism was suspected in each case.

Results: Eight of the 19 suspected foodborne illness patients fully satisfied the botulism case definition requirements set forth by the Saudi Arabian Public Health Authority (Weqaya). Among these eight patients, 2 (25%) were male and 6 (75%) were female, with a mean age of 23.25 ± 9.29 years (range: 12-38 years). The incubation period for our patients was 36.25 ± 26.26 h. Notable symptoms included dysphagia in all eight patients (100%), dysarthria, generalized weakness, nausea and vomiting in seven patients (88%), diplopia in four patients (50%), and stomach discomfort in three patients (38%). Of the eight cases, six required intubation, one mimicked brain death, and two were stable. The presence of Clostridium botulinum spores as the cause of the outbreak was confirmed by detecting botulinum spores in contaminated food.

Conclusion: Diplopia and dysarthria were the most common early sign of botulism. Early manifestations may include respiratory symptoms without any musculoskeletal symptoms. or nausea, vomiting and disorientation.

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来源期刊
CiteScore
10.70
自引率
1.40%
发文量
57
审稿时长
19 weeks
期刊介绍: The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
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