{"title":"通过偶氮甲基酰化物的 [2+2]/[2+3] 环加成法合成多取代的融合吡咯烷","authors":"Chunyan Ou, Jian Wang, Pingping Yin, Bin Chen, Ping Hu, Bi-Qin Wang, Peng Cao, Minghui Xu","doi":"10.1039/d4qo00483c","DOIUrl":null,"url":null,"abstract":"A general approach to densely substituted via [2+2]/[2+3]-cycloaddition between nonstabilized azomethine ylide, alkyne and silyl enol ether was elaborated. This approach not only allowed preparation of novel molecules but also significantly simplified synthesis of the existing ones. 3-Azabicyclo[3.2.0]heptanes which contained polysubstituted cyclobutanes could be obtained in medium to good yield with excellent diastereoselectivity.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of Polysubstituted Fused Pyrrolidines via [2+2]/[2+3] Cycloaddition of Azomethine Ylides\",\"authors\":\"Chunyan Ou, Jian Wang, Pingping Yin, Bin Chen, Ping Hu, Bi-Qin Wang, Peng Cao, Minghui Xu\",\"doi\":\"10.1039/d4qo00483c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A general approach to densely substituted via [2+2]/[2+3]-cycloaddition between nonstabilized azomethine ylide, alkyne and silyl enol ether was elaborated. This approach not only allowed preparation of novel molecules but also significantly simplified synthesis of the existing ones. 3-Azabicyclo[3.2.0]heptanes which contained polysubstituted cyclobutanes could be obtained in medium to good yield with excellent diastereoselectivity.\",\"PeriodicalId\":97,\"journal\":{\"name\":\"Organic Chemistry Frontiers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Chemistry Frontiers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4qo00483c\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4qo00483c","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Synthesis of Polysubstituted Fused Pyrrolidines via [2+2]/[2+3] Cycloaddition of Azomethine Ylides
A general approach to densely substituted via [2+2]/[2+3]-cycloaddition between nonstabilized azomethine ylide, alkyne and silyl enol ether was elaborated. This approach not only allowed preparation of novel molecules but also significantly simplified synthesis of the existing ones. 3-Azabicyclo[3.2.0]heptanes which contained polysubstituted cyclobutanes could be obtained in medium to good yield with excellent diastereoselectivity.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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