一例诊断不明确的病例:一名儿科患者的高级别黑色素细胞瘤与气球细胞黑色素瘤。

IF 1.6 4区 医学 Q3 DERMATOLOGY Journal of Cutaneous Pathology Pub Date : 2024-06-04 DOI:10.1111/cup.14664
Serena Shimshak MD, Olayemi Sokumbi MD, Ruifeng Guo MD, PhD, Dawn Marie R. Davis MD, Katherine B. Geiersbach MD, Nneka I. Comfere MD
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引用次数: 0

摘要

一名 11 岁的女性患者从外院转来,她的红褐色结节逐渐增大,诊断性活组织检查和随后的切除术显示,该结节具有气球细胞痣和高级别黑色素细胞瘤的特征,且严重不典型。在对最初的活检标本和分子数据进行复查后,我们认为诊断结果与伴有气球细胞变化的高级别黑色素细胞瘤一致,同时考虑到组织病理学和基因异常导致的气球细胞黑色素瘤的可能性。在本病例研究中,我们讨论了这一罕见儿科病例的关键诊断因素,并强调了黑色素细胞瘤和气球细胞黑色素瘤的重要病理和临床特征。
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A case of diagnostic uncertainty: High-grade melanocytoma versus balloon cell melanoma in a pediatric patient

An 11-year-old female was referred from an outside institution after a diagnostic biopsy and subsequent excision of a progressively enlarging reddish-brown nodule demonstrated features concerning for a balloon cell nevus with severe atypia versus a high-grade melanocytoma. Upon review of the initial biopsy specimen and molecular data, we favored the diagnosis to be consistent with a high-grade melanocytoma with balloon cell changes while considering the possibility of balloon cell melanoma due to concerning histopathologic and genetic abnormalities. In this case study, we discuss critical diagnostic considerations in this rare pediatric case and highlight important pathologic and clinical features of melanocytomas and balloon cell melanoma.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
期刊最新文献
Evaluation of Heterogeneity in the Coding Region of BRAF, MAP2K1, and MAP2K2 Genes in Primary and Metastatic Melanomas. The Spectrum of Cutaneous Granulomatous Inflammation and Detection of Rubella Virus in Skin Biopsies of Patients With Common Variable Immune Deficiency. Cutaneous Facial Nodule: A Presenting Sign of Metastatic Pulmonary Enteric Adenocarcinoma. Martin C. Mihm, Jr. Role in MGH Pigmented Lesion Clinic-50 Years Ago (1973). Study of Microsatellite Instability by Immunohistochemistry in a Cohort of Patients With Melanoma.
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