母亲饮食不足后补充欧米伽-3 脂肪酸对青少年焦虑症和微神经胶质细胞形态的影响。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2024-10-01 Epub Date: 2024-06-06 DOI:10.1037/bne0000584
Alina P Bogachuk, David S Jacobs, Bita Moghaddam
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引用次数: 0

摘要

母体缺乏ω-3 多不饱和脂肪酸(n-3 PUFA)是儿童和青少年患焦虑症和其他情绪障碍的潜在风险因素。在这里,我们使用了一种先前表征过的母鼠 n-3 PUFA 饮食缺乏模型,以确定断奶后补充对青少年焦虑样行为的影响。我们重点研究了两种焦虑模型:通过高架加迷宫测试的先天性焦虑和一种新的习得性焦虑操作模型,在该模型中,动物学习到行为可能与伤害的可变概率有关。鉴于最近的基础和临床研究表明,焦虑和 n-3 PUFA 缺乏对炎症过程和小胶质细胞结构与功能的其他不良影响有关,我们还评估了饮食缺乏模型和补充剂对多个脑区的青少年小胶质细胞形态的影响。我们发现,男性和女性青少年 n-3 PUFA 缺乏组都表现出先天性焦虑增加,但只有女性表现出学习性焦虑增强。断奶后补充营养对先天性焦虑没有显著影响,但对女性的学习性焦虑有改善作用。因此,补充营养对青少年焦虑的有益影响可能具有性别特异性,并取决于焦虑的类型。我们还发现,缺乏 n-3 PUFA 会影响青少年杏仁核和黑质脑区的小胶质细胞功能,但不会影响间叶脑区。总之,这些数据表明,虽然 n-3 PUFA 膳食补充剂可有效减轻青少年的焦虑,但这种效果与环境、性别和大脑网络有关。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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Impact of supplementation with omega-3 fatty acids after maternal dietary deficiency on adolescent anxiety and microglial morphology.

Dietary maternal deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA) is a potential risk factor for the development of anxiety and other mood disorders in children and adolescents. Here, we used a previously characterized maternal n-3 PUFA dietary deficiency model in rats to determine the impact of postweaning supplementation on adolescent anxiety-like behaviors. We focused on two models of anxiety: innate anxiety tested by the elevated plus maze and a novel operant model of learned anxiety where animals learn that actions may be associated with a variable probability of harm. Given that recent basic and clinical studies have associated anxiety and other adverse effects of n-3 PUFA deficiency on inflammatory processes and microglial structure and function, we also assessed the impact of our dietary deficiency model and supplementation on adolescent microglial morphology in multiple brain regions. We found that the male and female adolescent n-3 PUFA-deficient groups exhibit increased innate anxiety, but only females showed enhanced learned anxiety. Supplementation after weaning did not significantly affect innate anxiety but ameliorated learned anxiety in females. Thus, the beneficial effects of supplementation on adolescent anxiety may be sex-specific and depend on the type of anxiety. We also found that n-3 PUFA deficiency influences microglia function in adolescents in the amygdala and nigrostriatal, but not mesolimbic, brain regions. Collectively, these data suggest that while n-3 PUFA dietary supplementation may be effective in reducing adolescent anxiety, this effect is context-, sex-, and brain network-specific. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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