Suvi Alikärri, Ilkka Helenius, Susanna Heiskanen, Johanna Syvänen, Teemu Kemppainen, Eliisa Löyttyniemi, Mika Gissler, Arimatias Raitio
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Associated anomalies were classified based on the EUROCAT criteria; minor anomalies were excluded.</p><p><strong>Results: </strong> There were 249 DA cases including 222 (89.2%) live births, 16 (6.4%) stillbirths, and 11 (4.4%) terminations. There was no significant change in the prevalence rates between 2004 and 2017. Live birth prevalence was 2.75/10,000 and total prevalence was 3.08/10,000 births. A total of 100 (40.2%) cases were isolated, 67 (26.9%) had other multiple congenital anomalies, and 83 (33.3%) were syndromic. There were no terminations in isolated DA. Most associated anomalies were cardiac (36.1%), followed by other gastrointestinal tract anomalies (23.7%) and limb deformities/defects (7.2%). Trisomy 21 was observed in 63 cases (25.3%). Neonatal mortality was 3.6% (<i>n</i> = 8) and at 1 year 95.0% were alive. Both neonatal and infant mortalities were associated with cardiac anomalies (<i>p</i> < 0.001 and <i>p</i> = 0.001, respectively). All neonatal deaths had associated cardiac defect(s).</p><p><strong>Conclusions: </strong> The prevalence of DA in Finland remains stable and among the highest reported. DA is often associated with cardiac anomalies, which portend a high risk for mortality. 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引用次数: 0
摘要
导言:十二指肠闭锁(DA)是最常见的小肠闭锁。本研究旨在评估2004-2017年间芬兰十二指肠闭锁的发病率、死亡率和相关畸形。材料与方法 这是一项基于芬兰卫生与福利研究所(Finnish Institute for Health and Welfare)和芬兰统计局(Statistics Finland)登记的全国性研究,其中包含所有活产、死产和终止妊娠的数据。根据 ICD-9 和 10 编码确定病例。相关畸形根据EUROCAT标准进行分类;轻微畸形除外。结果 249 例 DA 包括 222 例活产(89.2%)、16 例死胎(6.4%)和 11 例终止妊娠(4.4%)。2004 年至 2017 年间,患病率无明显变化。活产患病率为 2.75/10000,总患病率为 3.08/10000。100例(40.2%)为孤立畸形,67例(26.9%)伴有其他重大先天畸形,83例(33.3%)为综合征。孤立型先天性心脏病中没有终止妊娠的病例。大多数伴发畸形是心脏畸形(36.1%),其次是其他胃肠道畸形(23.7%)和肢体畸形/缺陷(7.2%)。有 63 例(25.3%)观察到 21 三体综合征。新生儿死亡率为 3.6%(8 例),一年后 95.0% 的婴儿存活。新生儿和婴儿死亡率均与心脏畸形有关(p
Duodenal Atresia in Finland from 2004 to 2017: Prevalence, Mortality, and Associated Anomalies-A Population-Based Study.
Introduction: Duodenal atresia (DA) is the most common atresia of the small bowel. This study aims to assess the prevalence, mortality, and associated anomalies related to DA in Finland from 2004 to 2017.
Material and methods: A nationwide study based on registers maintained by the Finnish Institute for Health and Welfare and Statistics Finland containing data on all live births and stillbirths and terminations of pregnancy. The cases were identified based on the ICD-9 and 10 (International Classification of Diseases revisions 9 and 10) codes. Associated anomalies were classified based on the EUROCAT criteria; minor anomalies were excluded.
Results: There were 249 DA cases including 222 (89.2%) live births, 16 (6.4%) stillbirths, and 11 (4.4%) terminations. There was no significant change in the prevalence rates between 2004 and 2017. Live birth prevalence was 2.75/10,000 and total prevalence was 3.08/10,000 births. A total of 100 (40.2%) cases were isolated, 67 (26.9%) had other multiple congenital anomalies, and 83 (33.3%) were syndromic. There were no terminations in isolated DA. Most associated anomalies were cardiac (36.1%), followed by other gastrointestinal tract anomalies (23.7%) and limb deformities/defects (7.2%). Trisomy 21 was observed in 63 cases (25.3%). Neonatal mortality was 3.6% (n = 8) and at 1 year 95.0% were alive. Both neonatal and infant mortalities were associated with cardiac anomalies (p < 0.001 and p = 0.001, respectively). All neonatal deaths had associated cardiac defect(s).
Conclusions: The prevalence of DA in Finland remains stable and among the highest reported. DA is often associated with cardiac anomalies, which portend a high risk for mortality. Despite the burden of associated anomalies, overall survival is high.
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