糖尿病孕妇新生儿体重与血清 BCAAs 之间的相关性。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nutrition & Diabetes Pub Date : 2024-06-05 DOI:10.1038/s41387-024-00301-6
Na Tang, Yajin Liu, Sa Yang, Mengyu Zhong, Dongqing Cui, Ou Chai, Yurong Wang, Yunwei Liu, Xuejiao Zhang, Zhimin Hou, Haipeng Sun
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引用次数: 0

摘要

背景:支链氨基酸(BCAAs),包括亮氨酸、异亮氨酸和缬氨酸,是哺乳动物必需的氨基酸。孕期母体摄入的 BCAAs 与新生儿的发育有关。同时,近年来 BCAAs 与胰岛素抵抗和糖尿病密切相关。妊娠糖尿病是一种常见的代谢性疾病。本研究旨在评估糖尿病孕妇的循环 BCAA 水平及其与新生儿发育的关系:方法:采用液相色谱-质谱联用系统测定了33名糖耐量正常孕妇、16名妊娠前2型糖尿病(PDGM)孕妇和15名妊娠期糖尿病(GDM)孕妇血清中BCAAs及其相应支链α-酮酸(BCKAs)代谢产物的浓度。在进行统计分析之前,对数据进行了正态分布和方差齐性检验。相关性用皮尔逊相关系数计算:结果:妊娠晚期PGDM妇女的母体血清中BCAAs和BCKAs水平高于健康妇女。同时,与健康孕妇相比,GDM 孕妇循环中的 BCAAs 和 BCKAs 没有明显变化。此外,PGDM 孕妇循环中的 BCAA 和 BCKA 水平与新生儿体重呈正相关。GDM 孕妇的循环亮氨酸水平与新生儿体重呈正相关。健康孕妇的 BCAA 和 BCKA 水平与新生儿体重无相关性:糖尿病孕妇血清中的 BCAAs 与新生儿体重呈正相关,PGDM 孕妇血清中 BCAAs 升高,而 GDM 孕妇血清中 BCAAs 不升高。这些发现凸显了早期识别高危人群并采取干预措施降低不良妊娠结局风险的潜在方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Correlation between newborn weight and serum BCAAs in pregnant women with diabetes.

Background: Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for mammals. Maternal BCAAs during pregnancy have been associated with newborn development. Meanwhile, BCAAs have been tightly linked with insulin resistance and diabetes in recent years. Diabetes in pregnancy is a common metabolic disorder. The current study aims to assess the circulating BCAA levels in pregnant women with diabetes and their relationship with neonatal development.

Methods: The serum concentrations of BCAAs and their corresponding branched-chain α-keto acids (BCKAs) catabolites in 33 pregnant women with normal glucose tolerance, 16 pregnant women with type 2 diabetes before pregnancy (PDGM), and 15 pregnant women with gestational diabetes mellitus (GDM) were determined using a liquid chromatography system coupled to a mass spectrometer. The data were tested for normal distribution and homogeneity of variance before statistical analysis. Correlations were computed with the Pearson correlation coefficient.

Results: The maternal serum BCAAs and BCKAs levels during late pregnancy were higher in women with PGDM than those in healthy women. Meanwhile, the circulating BCAAs and BCKAs showed no significant changes in women with GDM compared with those in healthy pregnant women. Furthermore, the circulating BCAA and BCKA levels in women with PGDM were positively correlated with the weight of the newborn. The circulating leucine level in women with GDM was positively correlated with the weight of the newborn. BCAA and BCKA levels in healthy pregnant women showed no correlation with newborn weight.

Conclusions: The serum BCAAs in pregnant women with diabetes, which was elevated in PGDM but not GDM, were positively correlated with newborn weight. These findings highlight potential approaches for early identification of high-risk individuals and interventions to reduce the risk of adverse pregnancy outcomes.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
期刊最新文献
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