2007-2021 年法国新生儿 B 群链球菌侵入性感染复发情况。

IF 5 2区医学 Q2 IMMUNOLOGY Journal of Infectious Diseases Pub Date : 2025-02-20 DOI:10.1093/infdis/jiae307

Ghalia Sbaa, Nicolas Delettre, Cécile Guyonnet, Sébastien Le Huu Nghia, Caroline Joubrel-Guyot, Céline Plainvert, Claire Poyart, Asmaa Tazi

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引用次数: 0

摘要

复发是 B 群链球菌（GBS）新生儿感染的一种罕见并发症。我们对 2007 年至 2021 年法国的 GBS 新生儿侵袭性感染进行了回顾性观察研究。共报告了1527例病例，其中36例（2.36%）为复发病例。复发病例主要涉及早产儿（68%）和低出生体重儿（72%），与高病毒性 GBS 克隆复合体 17（83%，OR 2.86，95% CI 1.18-6.92）有关。未发现耐受β-内酰胺的菌株，细菌全基因组测序也未发现与复发相关的任何特定特征。应开展大型队列研究，以解决这些不常见疾病的最佳治疗问题。

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Recurrent Group B Streptococcus Neonatal Invasive Infections, France, 2007-2021.

Recurrence is a rare complication of group B Streptococcus (GBS) neonatal infections. We conducted a retrospective observational study on GBS neonatal invasive infections in France from 2007 to 2021. A total of 1527 cases were reported, of which 36 (2.36%) were recurrent. Recurrence mainly concerned preterm (68%) and low-birth-weight (72%) infants and was associated with the hypervirulent GBS clonal complex 17 (83%; odds ratio, 2.86 [95% confidence interval, 1.18-6.92]). No β-lactam-tolerant strains were identified, and bacterial whole-genome sequencing could not reveal any specific feature associated with recurrence. Large-cohort studies should be undertaken to address the optimal management of these uncommon diseases.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.