NELL-1 作为石棉沉滞症相关膜性肾病的靶抗原--一份病例报告

Pub Date : 2024-06-04 DOI:10.25259/ijn_65_2024

B. Sundaram, Nabadwip Pathak, M. Ambroise, Selva Micheal Papou

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引用次数: 0

摘要

一名有长期石棉接触史的 80 岁男性患者 24 小时尿蛋白为 8 克，血清白蛋白为 1.7 克/分升。肾活检发现了膜性肾病的特征。免疫组化显示神经表皮样生长因子样 1（NELL1）阳性（2+/3+）。进一步评估发现，胸部计算机断层扫描（CT）意外发现了与石棉相关的胸膜斑块和左侧半胸腔容积减少，最终确诊为石棉沉滞症。该病例突显了石棉沉滞症与 NELL-1 阳性膜性肾病之间罕见的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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NELL-1 as a Target Antigen in Asbestosis Associated Membranous Nephropathy — A Case Report

An 80-year-old male with a history of prolonged asbestos exposure presented with 24-hour urine protein of 8 gm, and serum albumin of 1.7 gm/dl. Renal biopsy disclosed features of membranous nephropathy. Immunohistochemistry showed positivity for neural epidermal-like growth factor- like 1 (NELL1) (2+/3+). Further assessment uncovered an incidental finding of asbestos-related pleural plaques and left hemithorax volume loss on computed tomography (CT) chest, leading to a diagnosis of asbestosis. This case highlights the rare association between asbestosis and NELL-1 positive membranous nephropathy.

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