鉴定秀丽隐杆线虫 ced-3 基因镜像重复序列的硅学方法

Mamta Dhankhar, Deepti Yadav, Vikash Bhardwaj
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摘要

目的:真核生物基因组中的重复元件占很大一部分,与细胞内的各种分子功能有关。我们的研究目标是确定一种特殊类型的重复,即完整的 ced-3 细胞凋亡基因及其外显子中的镜像重复。研究方法我们采用了一种简单的计算方法来搜索高脚线虫(C. elegans)的八个外显子和完整 ced-3 基因中的镜像重复序列。elegans 是一种广泛用于研究遗传学和发育生物学的模式生物,而 ced-3 是导致细胞死亡的主要凋亡基因。研究结果我们在 elegans ced-3 基因的不同区域中发现了 140 个镜像重复序列。这些已发现的镜像重复序列并不局限于秀丽隐杆线虫的基因组,它们还散布在低等隐杆线虫、热带爪蟾和黑腹果蝇的基因组中。新颖性:这项研究工作是首次尝试描述完整的 ced-3 基因及其外显子中的镜像重复序列。目前还没有人研究过 elegans ced-3 细胞凋亡基因中的镜像重复序列。镜像重复有可能形成三重 DNA,而且与多种神经系统疾病有关。即将进行的研究将有助于我们探索这些已发现的镜像重复序列的功能和性质。关键词重复元件 镜像重复秀丽隐杆线虫和 ced-3 基因
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In silico Approach for the Identification of Mirror Repeats within ced-3 Gene of Caenorhabditis elegans
Objectives: The repetitive elements within the genome of eukaryotes form a significant portion and are associated with various molecular functions within a cell. The goal of our study is to determine a special type of repeat i.e., mirror repeat within complete ced-3 apoptotic gene and its exons. Methods: A simple computational approach was used to search mirror repeats within the eight exons and complete ced-3 gene of Caenorhabditis elegans (C. elegans). C. elegans is a model organism widely used to study genetics, and developmental biology and ced-3 is the main apoptotic gene responsible for cell death. Findings: We identified 140 mirror repeats within the different regions of the ced-3 gene of C. elegans. These identified mirror repeats are not restricted to the genome of C. elegans but are scattered among the genome of C. vulgaris, Xenopus tropicalis and Drosophila melanogaster. Novelty: This research work is the very first endeavor to characterize mirror repeats within the complete ced-3 gene and its exons. Nobody has been studied mirror repeats within ced-3 apoptotic gene of C. elegans. Mirror repeat has the potential to form triplex DNA and is also associated with several neurological disorders. Forthcoming studies will help us to explore the functions and nature of these identified mirror repeats. Keywords: Repetitive elements, mirror repeats, Caenorhabditis elegans and ced-3 gene
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