与 COVID-19 有关的感染后格林巴利综合征:罕见病例报告

A. Ahizoune, Ahmed Bourazza
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摘要

吉兰-巴雷综合征(GBS)是一种罕见的免疫介导的周围神经系统炎症性疾病,推测是由之前的感染引发的。在 COVID-19(冠状病毒病)大流行的时代,世界各地都出现了与 COVID-19 相关的副感染/感染后 GBS 病例。在此,我们报告了一名 55 岁的男性患者,他因乏力、发热和咳嗽而入院,病因与 COVID-19 有关。后来,在COVID-19症状消失后,他开始出现上升性反射性四肢瘫痪。脑脊液和非脑脊液检查结果均支持 GBS 诊断,尤其是纯运动型 AIDP 亚型。抗神经节苷脂抗体呈阴性。腰骶部磁共振成像显示马尾根造影剂增强。接受静脉注射免疫球蛋白治疗后,患者恢复良好。
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Post-Infectious Guillain Barré Syndrome Related to COVID-19: Unusual Case Report
Guillain-Barré Syndrome (GBS) is a rare immune mediated inflammatory disease of the peripheral nervous system that is presumed to be triggered by preceding infections. In the era of pandemic COVID-19 (coronavirus disease), there is an emerging case of para/post infectious GBS associated to COVID-19 that are described worldwide. Here, we report a 55-years-old man who was admitted for fatigue, fever and cough related to covid-19. Later, after disappearing of covid-19 symptoms he began presenting an ascending areflexic tetraparesis. CSF and NCS were in favour of GBS diagnosis, in particular pure motor AIDP subtype. Antigangliosides antibodies were negative. Lumbosacral MRI showed contrast enhancement of cauda equina roots. The outcome was good after receiving intravenous immunoglobulins treatment.
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