基于 3.0 T 临床磁共振成像的新型微线圈在实验小鼠高分辨率成像中的应用价值

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Tomography Pub Date : 2024-06-01 DOI:10.3390/tomography10060064

Xueke Qiu, Yang Liu, Fajin Lv

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引用次数: 0

摘要

临床磁共振扫描仪（场强≤ 3.0 T）对实验小鼠的高分辨率成像效果有限。本研究介绍了一种新型磁共振微线圈，旨在提高信噪比（SNR）和对比度-噪声比（CNR），从而改善使用临床磁共振扫描仪对实验小鼠进行高分辨率成像的效果。最初，利用一个模型来确定新型微线圈可达到的最大空间分辨率。随后，12 只 C57BL/6JGpt 小鼠被纳入这项研究，并使用新型微线圈对其进行扫描。此外，还选择了一个临床用柔性线圈进行对比分析。两个线圈的扫描方法一致。对两个线圈在小鼠组织和器官上产生的成像清晰度、噪声和伪影进行了主观评价，同时对大脑、脊髓和肝脏的信噪比和有线信噪比进行了客观测量。比较了两个线圈产生的图像差异。结果表明，新型微线圈的最大空间分辨率为 0.2 毫米。此外，使用新型微线圈获得的图像的主观评价优于柔性线圈（P < 0.05）。使用新型微线圈测量的大脑、脊髓和肝脏的 SNR 和 CNR 明显高于使用柔性线圈测量的结果（P < 0.001）。我们的研究表明，新型微线圈能有效提高实验小鼠临床磁共振扫描仪的图像质量。

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Application Value of a Novel Micro-Coil in High-Resolution Imaging of Experimental Mice Based on 3.0 T Clinical MR

The clinical magnetic resonance scanner (field strength ≤ 3.0 T) has limited efficacy in the high-resolution imaging of experimental mice. This study introduces a novel magnetic resonance micro-coil designed to enhance the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), thereby improving high-resolution imaging in experimental mice using clinical magnetic resonance scanners. Initially, a phantom was utilized to determine the maximum spatial resolution achievable by the novel micro-coil. Subsequently, 12 C57BL/6JGpt mice were included in this study, and the novel micro-coil was employed for their scanning. A clinical flexible coil was selected for comparative analysis. The scanning methodologies for both coils were consistent. The imaging clarity, noise, and artifacts produced by the two coils on mouse tissues and organs were subjectively evaluated, while the SNR and CNR of the brain, spinal cord, and liver were objectively measured. Differences in the images produced by the two coils were compared. The results indicated that the maximum spatial resolution of the novel micro-coil was 0.2 mm. Furthermore, the subjective evaluation of the images obtained using the novel micro-coil was superior to that of the flexible coil (p < 0.05). The SNR and CNR measurements for the brain, spinal cord, and liver using the novel micro-coil were significantly higher than those obtained with the flexible coil (p < 0.001). Our study suggests that the novel micro-coil is highly effective in enhancing the image quality of clinical magnetic resonance scanners in experimental mice.

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.