普萘洛尔减弱条件性情境厌恶的建立:在预期恶心和呕吐动物模型中与 MK-801 相比的不同效果。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI:10.1097/FBP.0000000000000779
Çinar Furkan İlhan, Esra Ülke, Gonzalo P Urcelay, Sezen Kişlal
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引用次数: 0

摘要

癌症患者经常会因巴甫洛夫条件反射而出现预期性恶心和呕吐(ANV)。已知N-甲基-D-天冬氨酸受体和β-肾上腺素能受体都能介导记忆的形成,但它们在恶心呕吐发生过程中的作用仍不清楚。本研究使用条件性情境厌恶(CCA)范例(ANV的动物模型)来评估在CCA训练后立即给予β肾上腺素能受体拮抗剂普萘洛尔或N-甲基-D-天冬氨酸受体拮抗剂MK-801是否会影响CD1雄性小鼠日后的CCA表达。在实验 1 中,三组小鼠被注射氯化锂(LiCl),以诱导小鼠在新环境中产生厌恶感,从而导致 CCA。对照组注射氯化钠(NaCl)。调节后,氯化锂处理组中的两组接受不同剂量的 MK-801(0.05 或 0.2 毫克/千克),其余氯化锂处理组和氯化钠处理组接受第二次氯化钠注射。在实验 2 中,两组注射氯化锂,一组注射氯化钠。调节后,锂盐处理组中的一组接受普萘洛尔注射(10 毫克/千克)。其余的氯化锂处理组和氯化钠处理组则注射氯化钠。72 小时后,在调节背景下测量所有组的耗水量。与接受氯化锂和普萘洛尔治疗的动物相比,接受氯化钠和普萘洛尔治疗的动物的耗水量水平相似,这表明普萘洛尔而非 MK-801 可减轻条件反射后的 CCA。这些研究结果表明,β肾上腺素能受体的激活对 CCA 的发展至关重要。因此,普萘洛尔可能是治疗高危癌症患者的一种新方法。
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Propranolol attenuates the establishment of conditioned context aversions: differential effects compared to MK-801 in an animal model of anticipatory nausea and vomiting.

Cancer patients often experience anticipatory nausea and vomiting (ANV) due to Pavlovian conditioning. Both N-methyl-D-aspartate and beta-adrenergic receptors are known to mediate memory formation, but their role in the development of ANV remains unclear. This study used a conditioned context aversion (CCA) paradigm, an animal model for ANV, to assess whether administration of the beta-adrenergic receptor antagonist propranolol or the N-methyl-D-aspartate receptor antagonist MK-801 immediately after CCA training has an effect on the later expression of CCA in CD1 male mice. In experiment 1, three groups were injected with lithium chloride (LiCl) to induce aversion in a novel context, resulting in CCA. A control group was injected with sodium chloride (NaCl). Following conditioning, two of the LiCl-treated groups received different doses of MK-801 (0.05 or 0.2 mg/kg), while the remaining LiCl-treated and NaCl-treated groups received a second NaCl injection. In experiment 2, two groups were injected with LiCl, and one group was injected with NaCl. After conditioning, one of the LiCl-treated groups received a propranolol injection (10 mg/kg). The remaining LiCl-treated and NaCl-treated groups received NaCl injections. Water consumption was measured in all groups 72 h later within the conditioning context. Postconditioning administration of propranolol, but not MK-801, attenuated CCA, as revealed by similar levels of water consumption in animals that received LiCl and propranolol relative to NaCl-treated animals. These findings suggest that beta-adrenergic receptor activation is crucial for the development of CCA. Therefore, propranolol may represent a novel therapeutic approach for cancer patients at high risk of ANV.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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