m6A 修饰在神经干细胞增殖、分化和自我更新中的复杂作用以及对记忆和神经退行性疾病的影响。

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-06-01 Epub Date: 2024-06-03 DOI:10.4103/NRR.NRR-D-23-01872
Yanxi Li, Jing Xue, Yuejia Ma, Ke Ye, Xue Zhao, Fangliang Ge, Feifei Zheng, Lulu Liu, Xu Gao, Dayong Wang, Qing Xia
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引用次数: 0

摘要

摘要:N6-甲基腺苷(m6A)是真核细胞中最普遍和最保守的RNA修饰,几乎深刻影响着mRNA代谢的所有方面。mRNA在神经干细胞的形成和神经再生中发挥着关键作用,它高度集中并积极参与这些过程。m6A 修饰水平和相关酶蛋白表达水平的变化可导致神经功能紊乱,并诱发神经系统疾病。此外,神经干细胞的增殖和分化以及神经再生与记忆功能和神经退行性疾病密切相关。本文全面综述了 m6A 在神经干细胞增殖、分化和自我更新中的作用及其在记忆和神经退行性疾病中的影响。这些观察到的矛盾可能源于 m6A 的时间特异性及其在不同发育阶段对神经干细胞的不同影响。同样,m6A 对不同类型记忆的不同影响可能是由于特定脑区参与了记忆的形成和回忆。不同神经退行性疾病(尤其是阿尔茨海默病和帕金森病)模型中 m6A 水平的不一致性表明,这些差异与受影响脑区的变化有关。值得注意的是,与正常帕金森病模型相比,在暴露于锰的帕金森病模型中观察到的 m6A 水平的相反变化进一步强调了 m6A 在神经退行性过程中作用的复杂性。m6A在神经干细胞增殖、分化和自我更新中的作用及其在记忆和神经退行性疾病中的影响似乎相互矛盾。这些矛盾可能归因于 m6A 的时间特异性及其对不同脑区和不同环境的不同影响。
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The complex roles of m 6 A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases.

N6-methyladenosine (m 6 A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m 6 A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m 6 A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m 6 A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m 6 A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m 6 A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m 6 A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m 6 A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m 6 A's role in neurodegenerative processes. The roles of m 6 A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be attributed to the time-specific nature of m 6 A and its varying effects on distinct brain regions and in different environments.

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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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