血栓增强标志对急性基底动脉闭塞中风亚型和再通的预测价值。

IF 5.8 3区 医学 Q1 CLINICAL NEUROLOGY European Stroke Journal Pub Date : 2024-06-06 DOI:10.1177/23969873241256251
Guangchen He, Sheng Guo, Hui Fang, Haoyang Xu, Runjianya Ling, Haitao Lu, Yueqi Zhu
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引用次数: 0

摘要

背景:血栓增强征(TES)与心栓性卒中和前部缺血性卒中的首次血管造影失败有关。然而,基底动脉闭塞(BAO)的 TES 与卒中亚型和血管内治疗(EVT)后再通状况之间的关系仍不清楚:这项回顾性研究纳入了 2020 年 1 月至 2023 年 9 月间接受 EVT 的急性 BAO 连续患者。每位患者都接受了基线非对比计算机断层扫描(CT)和 CT 血管造影。两名独立阅读者对是否存在 TES 进行评估。中风类型根据 ORG 10172 急性中风治疗试验进行分类。EVT术后脑梗塞溶栓评分达到2b-3分即为再通成功。对TES阳性组和TES阴性组的临床和介入参数以及组织病理学血栓检查结果进行了比较。采用单变量和多变量分析方法分析了TES与中风亚型和再通状况之间的关系:共有151名患者参与分析,其中116人(77%)表现为TES。TES 与心源性栓塞和隐源性中风有明显相关性(几率比 [OR]:8.56;95% 置信区间:3.49-22.4;P = 0.002),红细胞比例较低(P = 0.044)。在调整基线混杂因素后,TES阳性组与TES阴性组相比显示出良好的结果,包括更短的手术时间(p p = 0.010)、更高的首次通过成功率(p = 0.022)和更低的需要血管成形术和/或支架植入术的比例(p p = 0.003):基底动脉闭塞血栓切除术中,TES的可视化是识别心源性栓塞和隐源性卒中以及预测再通成功率的可靠、易得的标志物。
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Predictive value of thrombus enhancement sign for stroke subtype and recanalization in acute basilar-artery occlusion.

Background: Thrombus enhancement sign (TES) is associated with cardioembolic stroke and first-pass angiographic failure in anterior ischemic stroke. However, the relationship between TES and stroke subtype and recanalization status after endovascular treatment (EVT) in basilar artery occlusion (BAO) remains unknown.

Methods: This retrospective study included consecutive patients with acute BAO who underwent EVT between January 2020 and September 2023. Each patient underwent baseline non-contrast computed tomography (CT) and CT angiography. Two independent readers assessed the presence of TES. Stroke types were classified according to the Trial of ORG 10172 for Acute Stroke Treatment. Successful recanalization was defined as a modified Thrombolysis in Cerebral Infarction score of 2b-3 after EVT. Clinical and interventional parameters, along with histopathological thrombi examination results, were compared between the TES-positive and TES-negative groups. The associations between TES and stroke subtype and recanalization status were analyzed using univariate and multivariate analyses.

Results: A total of 151 patients were included in the analysis, among whom 116 (77%) exhibited TES. TES showed a significant correlation with cardioembolic and cryptogenic strokes (odds ratio [OR]: 8.56; 95% confidence interval: 3.49-22.4; p < 0.001), whereas the TES-positive thrombi were characterized by a higher fibrin/platelet proportion (p = 0.002) and lower erythrocyte proportion (p = 0.044). The TES-positive group demonstrated favorable outcomes compared to the TES-negative group, including a shorter procedure time (p < 0.001), lower number of thrombectomy attempts (p = 0.010), higher incidence of first pass success (p = 0.022), and lower rate of requiring rescue angioplasty and/or stenting (p < 0.001). In multivariate analysis, TES remained independently associated with successful recanalization (OR: 9.63; 95% CI: 2.33, 47.7; p = 0.003) after adjusting for baseline confounders.

Conclusions: Visualization of TES serves as a reliable and easily accessible marker for identifying cardioembolic and cryptogenic strokes and predicting recanalization success in thrombectomy for basilar artery occlusion.

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来源期刊
CiteScore
7.50
自引率
6.60%
发文量
102
期刊介绍: Launched in 2016 the European Stroke Journal (ESJ) is the official journal of the European Stroke Organisation (ESO), a professional non-profit organization with over 1,400 individual members, and affiliations to numerous related national and international societies. ESJ covers clinical stroke research from all fields, including clinical trials, epidemiology, primary and secondary prevention, diagnosis, acute and post-acute management, guidelines, translation of experimental findings into clinical practice, rehabilitation, organisation of stroke care, and societal impact. It is open to authors from all relevant medical and health professions. Article types include review articles, original research, protocols, guidelines, editorials and letters to the Editor. Through ESJ, authors and researchers have gained a new platform for the rapid and professional publication of peer reviewed scientific material of the highest standards; publication in ESJ is highly competitive. The journal and its editorial team has developed excellent cooperation with sister organisations such as the World Stroke Organisation and the International Journal of Stroke, and the American Heart Organization/American Stroke Association and the journal Stroke. ESJ is fully peer-reviewed and is a member of the Committee on Publication Ethics (COPE). Issues are published 4 times a year (March, June, September and December) and articles are published OnlineFirst prior to issue publication.
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